A New Deprotection Procedure of MTM Ether.
A New Deprotection Procedure of MTM Ether.
复制标题
MTM 以太的一种新的去保护程序。
作者：
Adachi;M.; Hashimoto;H.; Sakakibara;R.; Imazu;T.; Nishikawa;T.
开发了一种新的羟基保护基甲硫甲基(MTM)醚的脱保护方法。用MCPBA或氧酮氧化MTM，生成的亚砜在Pummerer重排条件下进行处理，得到乙酰氧基硫醚和/或乙酰氧基缩醛。产物的碱解以良好的产率提供了无保护的醇。描述了使用几种不同底物的反应的细节。
A new deprotection procedure of methylthiomethyl (MTM) ether, a protective group for the hydroxy group, was developed. MTM was oxidized with MCPBA or Oxone, and the resulting sulfoxide was treated under conditions of the Pummerer rearrangement, to give acetoxy sulfide and/or acetoxy acetal. Alkaline hydrolysis of the products provided the unprotected alcohols in good yields. Details of the reactions using several different substrates are described.