Sustained virologic response following HCV eradication in two brothers with X-linked agammaglobulinaemia
Sustained virologic response following HCV eradication in two brothers with X-linked agammaglobulinaemia
复制标题
DOI：
10.3748/wjg.15.3944
复制
发表时间：
2009-08-21
影响因子：
4.3
通讯作者：
Lee, John M.
中科院分区：
文献类型：
--
作者：
Houlihan, Diarmaid D.;Storan, Eoin R.;Lee, John M.
X-连锁无丙种球蛋白血症（XLA）是一种体液免疫缺陷综合征，其特征是从儿童开始就缺乏循环B淋巴细胞、血清免疫球蛋白缺乏或水平降低以及反复细菌感染。对于许多受影响的患者来说，定期使用免疫球蛋白治疗可以挽救生命。通过受污染的血液制品获得的丙型肝炎病毒（HCV）感染在该患者队列中被广泛描述。与免疫功能正常的个体相比，XLA患者的HCV感染自然史倾向于遵循更快速和侵袭性的过程。此外，标准抗病毒治疗在该患者队列中似乎不太有效。在这里，我们报告的情况下，两个兄弟与XLA谁感染丙型肝炎病毒通过受污染的血液制品。他们接受了为期六个月的干扰素α-2b和利巴韦林治疗。我们报告了持续的病毒学反应五年后完成治疗。(c)2009 WJG出版社和百世登。All rights reserved.
X-linked agammaglobulinaemia (XLA) is a humoral immunodeficiency syndrome characterized from childhood by the absence of circulating B lymphocytes, absent or reduced levels of serum immunoglobulin and recurrent bacterial infections. For many affected patients, regular treatment with immunoglobulin is life saving. Hepatitis C viral (HCV) infection acquired through contaminated blood products is widely described in this patient cohort. The natural history of HCV infection in patients with XLA tends to follow a more rapid and aggressive course compared to immunocompetent individuals. Furthermore, standard anti-viral therapy appears to be less efficacious in this patient cohort. Here we report the cases of two brothers with XLA who contracted HCV through contaminated blood products. They were treated with a six month course of Interferon alpha-2b and Ribavirin. We report a sustained virologic response five years after completing treatment. (c) 2009 The WJG Press and Baishideng. All rights reserved.