Hepatic-portal nutrient infustion: effect on feeding in intact and vagotomized rabbits.
Hepatic-portal nutrient infustion: effect on feeding in intact and vagotomized rabbits.
复制标题
肝门营养物输注：对完整兔子和迷走神经切断兔子喂养的影响。
作者：
M. Rezek;D. Novin
等渗葡萄糖的肝门输注不影响自由喂养兔子的食物摄入量。相比之下，通过相同途径注入的其他几种常量营养素及其一些代谢物会导致厌食症，然后导致长期吞咽不足。当在夜间进行相同的输注时，其持续时间通常会缩短。迷走神经切断术并没有显着改变对葡萄糖或其他实验物质的肝门输注的食物摄入反应。相关实验的结果表明，长期厌食并不是快速输注速度或普遍行为不适的结果。然而，当输注大多数致厌食物质后腹腔注射胰岛素时，厌食持续时间缩短，食物消耗增加。结果为先前研究的神经和体液肠道机制的迷走神经介导的调节作用提供了间接证据，通过将营养负荷直接注入肝门循环来绕过这些调节作用。
Hepatic-portal infusions of isotonic glucose did not influence food intake in free-feeding rabbits. In contrast, several other macronutrients and some of their metabolites, infused via the same route, cause anorexia followed by prolonged hypophagia. Its duration was generally decreased when the same infusions were performed during the nocturnal period. Vagotomy did not significantly alter the food intake responses to hepatic-portal infusions of either glucose or the other experimental substances. The results of related experiments have demonstrated that prolonged anorexia was not a consequence of the fast infusion rate or the generalized behavioral mallaise. However, when the infusions of most anorexigenic substances were followed by intraperitoneal administration of insulin, the duration of anorexia was shortened and food consumption was elevated. The results provided indirect evidence for the vagally mediated regulatory contribution of the previously studied neural and humoral intestinal mechanisms which are bypassed by infusing nutrient loads directly into the hepatic-portal circulation.