Intervention-induced changes in neural connectivity during motor preparation may affect cortical activity at motor execution.
Intervention-induced changes in neural connectivity during motor preparation may affect cortical activity at motor execution.
复制标题
运动准备过程中干预引起的神经连接变化可能会影响运动执行时的皮层活动。
DOI：
10.1038/s41598-020-64179-x
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发表时间：
2020
影响因子：
4.6
通讯作者：
Yao,Jun
中科院分区：
文献类型：
--
作者：
Wilkins,KevinB;Dewald,JuliusPA;Yao,Jun
有效的干预措施已经证明了通过重新利用同病灶资源来改善运动功能的能力，这对于即使患有严重慢性卒中的个体的手功能恢复也是至关重要和可行的。然而，以前的研究集中在与运动执行相关的大脑活动的变化。运动准备的变化如何促进运动执行的变化仍不清楚。为了解决这个问题，8名严重慢性轻偏瘫卒中患者参加了为期7周的器械辅助干预。然后，我们量化了运动准备过程中区域之间的耦合变化和运动执行时的地形皮层活动变化，这些变化分别针对孤立的手开放和使用高密度EEG的肩关节。我们假设，运动准备期间干预引起的皮质-皮质相互作用的变化将导致运动执行活动的变化，特别是对同侧半球的依赖增加。与这一假设一致，我们发现，干预后，个人显示出减少耦合从同病灶M1对病灶M1在伽玛频率在电机准备手开放。其次是减少活动的contralesional初级感觉运动皮层在运动执行。同样，在提升和开放，转移到负耦合内同病灶M1从γ到β频率伴随着增加同病灶初级感觉运动皮层活动的干预。总之，这些结果表明，在运动准备过程中，运动区域内或运动区域之间的耦合的干预引起的变化可能会影响执行时的皮质活动。
Effective interventions have demonstrated the ability to improve motor function by reengaging ipsilesional resources, which appears to be critical and feasible for hand function recovery even in individuals with severe chronic stroke. However, previous studies focus on changes in brain activity related to motor execution. How changes in motor preparation may facilitate these changes at motor execution is still unclear. To address this question, 8 individuals with severe chronic hemiparetic stroke participated in a device-assisted intervention for seven weeks. We then quantified changes in both coupling between regions during motor preparation and changes in topographical cortical activity at motor execution for both hand opening in isolation and together with the shoulder using high-density EEG. We hypothesized that intervention-induced changes in cortico-cortico interactions during motor preparation would lead to changes in activity at motor execution specifically towards an increased reliance on the ipsilesional hemisphere. In agreement with this hypothesis, we found that, following the intervention, individuals displayed a reduction in coupling from ipsilesional M1 to contralesional M1 within gamma frequencies during motor preparation for hand opening. This was followed by a reduction in activity in the contralesional primary sensorimotor cortex during motor execution. Similarly, during lifting and opening, a shift to negative coupling within ipsilesional M1 from gamma to beta frequencies was accompanied by an increase in ipsilesional primary sensorimotor cortex activity following the intervention. Together, these results show that intervention-induced changes in coupling within or between motor regions during motor preparation may affect cortical activity at execution.