TOCOPHEROLS AND 6-HYDROXY-CHROMAN-2-CARBONITRILE DERIVATIVES INHIBIT VASCULAR SMOOTH-MUSCLE CELL-PROLIFERATION BY A NONANTIOXIDANT MECHANISM
TOCOPHEROLS AND 6-HYDROXY-CHROMAN-2-CARBONITRILE DERIVATIVES INHIBIT VASCULAR SMOOTH-MUSCLE CELL-PROLIFERATION BY A NONANTIOXIDANT MECHANISM
复制标题
DOI：
10.1006/abbi.1995.1226
复制
发表时间：
1995-04-01
影响因子：
3.9
通讯作者：
AZZI, A
中科院分区：
文献类型：
--
作者：
BOSCOBOINIK, D;OZER, NK;AZZI, A
在血管平滑肌细胞中研究了两组类似化合物（一系列生育酚和一种6-羟基-色满-2-腈）的作用。已经发现这些分子的抗增殖和抗氧化性质之间的相关性很差，D-α-生育酚抑制细胞增殖，而D-α-生育酚醌既不抑制也不激活，D-β-生育酚，一种平滑肌细胞增殖的不良抑制剂，已经显示能够预防和逆转D-α-生育酚的抑制。可以得出结论，这里测试的生育酚和腈衍生物似乎通过非抗氧化机制抑制平滑肌细胞增殖。D-α-生育酚和D-β-生育酚之间的竞争表明两种分子存在共同的结合位点。(C)出版社：Academic Press
The effects of two groups of similar compounds, a series of tocopherols and one of 6-hydroxy-chroman-2-carbonitrile, have been studied in vascular smooth muscle cells. A poor correlation has been found between antiproliferative and antioxidant properties of these molecules, D-alpha-Tocopherol inhibits cell proliferation, while D-alpha-tocopherylquinone has been found neither to inhibit nor to activate, D-beta-Tocopherol, a poor inhibitor of smooth muscle cell proliferation, has been shown to be capable of preventing and reversing the inhibition by D-alpha-tocopherol. It is concluded that the tocopherols and carbonitrile derivatives tested here appear to inhibit smooth muscle cell proliferation by a nonantioxidant mechanism, The competition between D-alpha-tocopherol and D-beta-tocopherol suggests the existence of a common binding site for the two molecules. (C) 1995 Academic Press,Inc.