A randomized controlled trial on the effectiveness of 8-week high-intensity interval exercise on intrahepatic triglycerides, visceral lipids, and health-related quality of life in diabetic obese patients with nonalcoholic fatty liver disease
A randomized controlled trial on the effectiveness of 8-week high-intensity interval exercise on intrahepatic triglycerides, visceral lipids, and health-related quality of life in diabetic obese patients with nonalcoholic fatty liver disease
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DOI：
10.1097/md.0000000000014918
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发表时间：
2019-03-01
期刊：
影响因子：
1.6
通讯作者：
Soliman, Gaber S.
中科院分区：
文献类型：
--
作者：
Abdelbasset, Walid Kamal;Tantawy, Sayed A.;Soliman, Gaber S.
背景：非酒精性脂肪性肝病（NAFLD）患者的药物治疗有限。据报道，有氧运动可以有效地降低NAFLD的特征，尽管目前还没有明确的数据确定高强度间歇有氧运动对糖尿病肥胖NAFLD患者健康相关生活质量（HRQoL）的影响。目的：这是一项随机对照试验，旨在确定8周高强度间歇运动对糖尿病肥胖合并NAFLD患者肝内甘油三酯（IHTG）、内脏脂质和HRQoL的有效性。研究设计：2017年8月至12月，32名年龄在45 - 60岁的糖尿病肥胖NAFLD患者（21名男性，11名女性）入组本研究。随机分为2组，每组16例，高强度间歇（HII）运动组和对照组。HII组接受HII有氧运动计划，为期8周，同时接受NAFLD药物治疗，对照组只接受药物治疗，不进行任何运动干预。在初始评估和8周后项目结束时记录IHTG、内脏脂质和HRQoL的测试。结果：研究结束时，两组比较差异有统计学意义。这些研究结果显示，HII组在IHTG、VO2peak、内脏脂质、糖蛋白、血浆葡萄糖和HRQoL的所有维度上都有显著改善(P。05)。结论：8周高强度间歇有氧运动对糖尿病肥胖合并NAFLD患者的IHTG、内脏脂质和HRQoL有有益的影响。应努力和意识鼓励不同人群，特别是糖尿病肥胖NAFLD患者积极的生活方式。
Background: Medications are limited for patients with nonalcoholic fatty liver disease (NAFLD). It has been reported that aerobic exercise is effective in reducing the characteristics of NAFLD, although unclear data have ascertained the effects of high-intensity interval aerobic exercise on health-related quality of life (HRQoL) in diabetic obese patients with NAFLD. Objectives: This a randomized controlled trial aimed to ascertain the effectiveness of 8-week high-intensity interval exercise on intrahepatic triglycerides (IHTG), visceral lipids and HRQoL in diabetic obese patients with NAFLD. Study design: Between August and December 2017, 32 diabetic obese patients with NAFLD aged 45 to 60 years (21 men and 11 women) were enrolled in this study. They were randomly assigned to 2 groups, 16 patients in each group, high-intensity interval (HII) exercise and control groups. The HII group received a program of HII aerobic exercise for 8 weeks with medications of NAFLD and the control group received only medications without any type of exercise intervention. The test of IHTG, visceral lipids, and HRQoL were recorded at the initial assessment and at the end of the program after 8 weeks. Results: There were significant differences between the 2 groups at the end of the study. These study findings exhibited significant improvements in IHTG, VO2peak, visceral lipids, glycohemoglobin, plasma glucose, and all dimensions of HRQoL in the HII group (P .05) after the 8-week intervention. Conclusion: Eight-week high-intensity interval aerobic exercise has a beneficial effect on IHTG, visceral lipids, and HRQoL in diabetic obese patients with NAFLD. Effort and awareness should be dedicated to encouraging the active lifestyle among different population, especially diabetic obese patients with NAFLD.