ACTIVATION OF THE 5-HT1A RECEPTOR SUBTYPE INCREASES RAT PLASMA ACTH CONCENTRATION
ACTIVATION OF THE 5-HT1A RECEPTOR SUBTYPE INCREASES RAT PLASMA ACTH CONCENTRATION
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DOI：
10.1016/0014-2999(88)90178-1
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发表时间：
1988-03-15
影响因子：
5
通讯作者：
STAHL, SM
中科院分区：
文献类型：
--
作者：
GILBERT, F;BRAZELL, C;STAHL, SM
5-羟色胺能（5-HT）神经元通路可能通过下丘脑促肾上腺皮质激素释放激素（CRH）的作用调节垂体促肾上腺皮质激素（ACTH）的释放。选择性5-HT1A受体激动剂8-羟基-2-（二正丙胺）四肽（8-OH-DPAT），剂量依赖性（0.016-3 mg/kg s.c）增加大鼠血浆ACTH浓度。这种反应被已知具有5-HT1拮抗剂特性的(-)-pindolol立体选择性阻断，但不被(+)-pindolol, .beta阻断。1-或。2-或。1-肾上腺素受体，多巴胺，毒蕈碱，5-HT2或5-HT3受体拮抗剂。其他5-HT1A受体配体（丁螺环酮、异沙匹酮和庚螺环酮）也可诱导血浆ACTH升高。这些结果表明，激活5-HT1A受体可诱导大鼠脑垂体分泌ACTH。
Serotonergic (5-HT) neuronal pathways regulate the release of adrenocorticotropin hormone (ACTH) from the pituitary gland probably through the action of hypothalamic corticotropin-releasing hormone (CRH). 8-Hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), a selective 5-HT1A receptor agonist, dose dependently (0.016-3 mg/kg s.c.) increased rat plasma ACTH concentration. This response was blocked stereoselectively by (-)-pindolol, known to have 5-HT1 antagonist properties, but not by (+)-pindolol, .beta.1-, or .beta.2- or .alpha.1-adrenoceptor, dopamine, muscarinic, 5-HT2 or 5-HT3 receptor antagonists. Similar increases of plasma ACTH were induced by other 5-HT1A receptor ligands (buspirone, ipsapirone and gepirone). These results suggest that activation of the 5-HT1A receptor induces the secretion of ACTH from the rat pituitary gland.