rpoB genotypes of Mycobacterium tuberculosis Beijing family isolates from East Asian countries
rpoB genotypes of Mycobacterium tuberculosis Beijing family isolates from East Asian countries
复制标题
DOI：
10.1128/jcm.40.3.1091-1094.2002
复制
发表时间：
2002-03-01
影响因子：
9.4
通讯作者：
Douglas, JT
中科院分区：
文献类型：
--
作者：
Qian, LS;Abe, C;Douglas, JT
分析了来自中国、日本、韩国和台湾的66株Rif结核分枝杆菌分离株的rpoB基因的81 bp区域。在rpoB基因中检测到12个单核苷酸取代。最常见的突变是Ser-531（52%）、Asp-516（17%）和His-526（11%）。在7株（11%）分离株中未发现突变。50株北京分离株的Asp-516和His-526突变率分别为18%和12.5%和6.3%。不同的突变率可能反映了利福霉素类似物的选择。
The 81-bp region of the rpoB gene in 66 Rif Mycobacterium tuberculosis isolates from China, Japan, Korea, and Taiwan was analyzed. Twelve single,nucleotide substitutions in the rpoB gene were detected. The most prevalent mutations were at Ser-531 (52%), Asp-516 (17%), and His-526 (11%). Mutations were not found in seven (11%) of the isolates. Higher mutation rates in 50 Beijing family isolates were found than in other isolates for mutations at Asp-516 (18 and 12.5%,respectively) and His-526 (12 and 6.3%, respectively). The different rates of mutation may reflect the choice of rifamycin analogs.