A MODEL OF HIPPOCAMPAL FUNCTION
A MODEL OF HIPPOCAMPAL FUNCTION
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DOI：
10.1016/s0893-6080(05)80159-5
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发表时间：
1994-01-01
期刊：
影响因子：
7.8
通讯作者：
OKEEFE, J
中科院分区：
文献类型：
--
作者：
BURGESS, N;RECCE, M;OKEEFE, J
在自由运动的大鼠中记录的海马位置细胞的放电率图被视为一组在大鼠（二维）环境中的近似径向基函数。研究人员提出，这些放电场是在探索过程中根据“感觉输入”（对来自大鼠的线索距离的调整曲线响应）构建的，下游的细胞使用这些放电场来构建放电率图，该图近似于环境中任何期望的表面。结果表明，当大鼠在开阔区域自由移动时，位置细胞的放电阶段（相对于脑电图θ节律）包含了与大鼠相对位置的放电场信息。海马体功能模型中，海马体下游细胞的放电率图提供了一个“种群向量”，编码了大鼠从先前遇到的奖励地点的瞬时方向，使其能够导航到它。一个神经元模拟，只涉及目标位置的强化，与海马区的单细胞记录提供了很好的一致性，并且可以利用来自环境线索的感觉输入导航到开放区域的奖励点。系统只需要短暂的探索，进行潜在学习，并且在遇到目标位置一次后就可以返回到目标位置。
The firing rate maps of hippocampal place cells recorded in a freely moving rat are viewed as a set of approximate radial basis functions over the (2-D) environment of the rat. It is proposed that these firing fields are constructed during exploration from ''sensory inputs '' (tuning curve responses to the distance of cues from the rat) and used by cells downstream to construct firing rate maps that approximate any desired surface over the environment. It is shown that, when a rat moves freely in an open field, the phase of firing of a place cell (with respect to the EEG theta rhythm) contains information as to the relative position of its firing field from the rat. A model of hippocampal function is presented in which the firing rate maps of cells downstream of the hippocampus provide a ''population vector'' encoding the instantaneous direction of the rat from a previously encountered reward site, enabling navigation to it. A neuronal simulation, involving reinforcement only at the goal location, provides good agreement with single cell recording from the hippocampal region, and can navigate to reward sites in open fields using sensory input from environmental cues. The system requires only brief exploration, performs latent learning, and can return to a goal location after encountering it only once.