Natural product scaffolds as inspiration for the design and synthesis of 20S human proteasome inhibitors.
Natural product scaffolds as inspiration for the design and synthesis of 20S human proteasome inhibitors.
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DOI：
10.1039/d0cb00111b
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发表时间：
2020-12-01
影响因子：
4.1
通讯作者：
Tepe JJ
中科院分区：
文献类型：
--
作者：
Hubbell GE;Tepe JJ
The 20S proteasome is a valuable target for the treatment of a number of diseases including cancer, neurodegenerative disease, and parasitic infection. In an effort to discover novel inhibitors of the 20S proteasome, many reseaarchers have looked to natural products as potential leads for drug discovery. The following review discusses the efforts made in the field to isolate and identify natural products as inhibitors of the proteasome. In addition, we describe some of the modifications made to natural products in order to discover more potent and selective inhibitors for potential disease treatment. The 20S proteasome is a valuable target for the treatment of a number of diseases including cancer, neurodegenerative disease, and parasitic infection.
