Approaching the molecular origins of collective dynamics in oscillating cell populations.

Approaching the molecular origins of collective dynamics in oscillating cell populations.
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DOI:
10.1016/j.gde.2010.09.004
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发表时间:
2010-12
影响因子:
4
通讯作者:
Gregor, Thomas
Gregor, Thomas
中科院分区:
生物学2区
文献类型:
--
作者:
Mehta, Pankaj;Gregor, Thomas

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从群鸟到器官生成,再到成群的细菌菌落,生物系统经常表现出集体行为。在这里,我们回顾了最近的进展,我们在细胞群体的集体动力学的理解。我们认为,理解人口水平的振荡需要在三个不同层次的复杂性:在孤立的细胞,同质的人口,空间结构的人口的水平下研究系统。我们将讨论这一挑战所带来的实验和理论挑战,并强调新的实验技术与物理学中的概念工具相结合时,可以帮助我们克服这些挑战。
From flocking birds, to organ generation, to swarming bacterial colonies, biological systems often exhibit collective behaviors. Here, we review recent advances in our understanding of collective dynamics in cell populations. We argue that understanding population-level oscillations requires examining the system under consideration at three different levels of complexity: at the level of isolated cells, homogenous populations, and spatially structured populations. We discuss the experimental and theoretical challenges this poses and highlight how new experimental techniques, when combined with conceptual tools adapted from physics, may help us overcome these challenges.
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