The Interaction of Fibroblast Growth Factor/Fibroblast Growth Factor Receptor and FGF Inhibitors
The Interaction of Fibroblast Growth Factor/Fibroblast Growth Factor Receptor and FGF Inhibitors
复制标题
DOI：
--
复制
发表时间：
2001
影响因子：
0.3
通讯作者：
F. Hong
中科院分区：
文献类型：
--
作者：
F. Hong
成纤维细胞生长因子（FGF）家族至少包含19个成员，在胚胎发生、血管形成、神经系统生长以及发育和病理状态中发挥重要作用。为了研究FGF/FGFR相互作用的机制，大量的研究工作集中在FGF和FGFR的结构和功能上。已经鉴定了aFGF和bFGF的肝素结合结构域以及bFGF的受体结合结构域。对FGFR的肝素结合区和配体结合区进行了定位。在此基础上，提出了FGF/FGFR相互作用的两种模型，并开发了许多核苷酸、核苷酸和肽类抑制剂。这些抑制剂在抗癌药物的设计中可能发挥重要作用。
The fibroblast growth factor (FGF) family contains at least nineteen members that play important roles in embryogenesis, vascularization, neuron system growth and in development and pathological states. In order to study the mechanism of interaction of FGF/FGFR, plenty of research work was focused on the study of structure and function of FGF and FGFR. Heparin binding domain of aFGF and bFGF, and receptor binding domain of bFGF have been identified. Heparin binding domain and ligands binding domain of FGFR also were localized. Based on the research, two models of interaction of FGF/FGFR were presented and many nucleotide, saccharides and peptide inhibitors were developed. The inhibitors may play an important role in the designing of anti cancer drug.