Effect of panretinal photocoagulation on choroidal circulation in the foveal region in patients with severe diabetic retinopathy
Effect of panretinal photocoagulation on choroidal circulation in the foveal region in patients with severe diabetic retinopathy
复制标题
DOI：
10.1136/bjo.2007.136028
复制
发表时间：
2008-10-01
影响因子：
4.1
通讯作者：
Yoshida, A.
中科院分区：
文献类型：
--
作者：
Takahashi, A.;Nagaoka, T.;Yoshida, A.
目的：目的：研究重度增殖性糖尿病视网膜病变（proliferative diabetic retinopathy，PDR）患者行全视网膜光凝（panretinalphotocoagulation，PRP）治疗后黄斑区脉络膜血流（choroidalbloodflow，CBF）的变化。所有患者均接受了4次分散PRP。我们测量了脉络膜血流速度（CBVel），脉络膜血容量（CBVel）和CBF在中心凹区域前和1个月后PRP使用激光多普勒flowmeter.Results：黄斑水肿没有发展后PRP在任何治疗的眼睛。PRP后1个月，平均CBVel（311.2（SD 61.2）Hz）与基线（327.1（74.1）Hz）相比无显著变化（p=0.17）。相比之下，平均CBF和CBF值显著增加了51%，（从基线的0.37（0.12）任意单位（Au）到0.52（0.16）Au，p=0.0025）和46%（从基线时的7.3（2.4）Au至10.4（4.4）Au，p=0.0014）。这些结果表明，PRP可能会增加严重糖尿病视网膜病变眼中心凹区域的CBF。目前的结果可能是由于在中心凹区域的脉络膜血管扩张。
Aim: To study alterations in choroidal blood flow (CBF) in the foveal region after panretinal photocoagulation (PRP) in patients with severe proliferative diabetic retinopathy.Methods: Seventeen eyes of 17 patients with severe non-proliferative diabetic retinopathy (PDR) or with non-high-risk PDR and no macular oedema before PRP were included. All patients underwent four sessions of scatter PRP. We measured the choroidal blood velocity (CBVel), choroidal blood volume (CBVol) and CBF in the foveal region before and 1 month after PRP using a laser Doppler flowmetry.Results: Macular oedema did not develop after PRP in any treated eyes. One month after PRP, there was no significant change in the mean CBVel (311.2 (SD 61.2) Hz) compared with baseline (327.1 (74.1) Hz) (p=0.17). In contrast, the mean CBVol and CBF values increased significantly by 51% ( from 0.37 (0.12) arbitrary units (au) at baseline to 0.52 (0.16) au, p=0.0025) and 46% ( from 7.3 (2.4) au at baseline to 10.4 (4.4) au, p=0.0014), respectively, 1 month after PRP.Conclusion: These results indicate that PRP may increase the CBF in the foveal region in eyes with severe diabetic retinopathy. The current results may be caused by vasodilation of the choriocapillaries in the foveal region.