Phencyclidine-induced catalepsy in pigeons: specificity and stereoselectivity.
Phencyclidine-induced catalepsy in pigeons: specificity and stereoselectivity.
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苯环己哌啶诱导的鸽子僵直症：特异性和立体选择性。
DOI：
10.1016/0014-2999(84)90070-0
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发表时间：
1984
影响因子：
5
通讯作者：
BurkeJr,TR
中科院分区：
文献类型：
--
作者：
Koek,W;Woods,JH;Rice,KC;Jacobson,AE;Huguenin,PN;BurkeJr,TR
本文描述了一种快速评估苯环利定类药物的催化活性（直立丧失、不滴头和不闭眼）的程序。苯环利定和氯胺酮的单次和累积给药程序产生了类似的结果。戊巴比妥在一定剂量下会导致倒立丧失，同时还会导致头下垂和闭眼。氯胺酮、1-（1-苯基环己基）-3-甲基哌啶和α-二恶二醇的d-异构体均能诱导猝睡。该方法适用于研究可能与苯环利定受体相互作用的化合物。
A procedure is described for the rapid assessment of cataleptic activity (loss of righting, without head-drop and without eye closure) of phencyclidine-type drugs. Single- and cumulative-dosing procedures with phencyclidine and ketamine produced similar results. Pentobarbital produced loss of righting at doses which also induced head-drop and eye closure. Catalepsy was induced exclusively by the d-isomers of ketamine, 1-(1-phenylcyclohexyl)-3-methylpiperidine and α-dioxadrol. The procedure is suitable for studying compounds which may interact with phencyclidine receptors.