Serum cotinine concentration and self-reported smoking during pregnancy.
Serum cotinine concentration and self-reported smoking during pregnancy.
复制标题
DOI：
10.1093/oxfordjournals.aje.a009633
复制
发表时间：
1998-08
影响因子：
5
通讯作者：
M. Klebanoff;Richard J. Levine;J. Clemens;R. Dersimonian;D. Wilkins
中科院分区：
文献类型：
--
作者：
M. Klebanoff;Richard J. Levine;J. Clemens;R. Dersimonian;D. Wilkins
虽然在怀孕期间，母体血清可替宁浓度与不良结局之间的相关性比自我报告的吸烟与此类结局之间的相关性更好，但很少有妊娠研究测量可替宁浓度以确定女性吸烟量。本研究评估的准确性，自我报告的吸烟在怀孕期间进行血清可替宁测定448名妇女注册的围产期合作项目（1959年至1966年）。基于血清可替宁浓度>10 ng/ml代表主动吸烟的假设，94.9%否认吸烟的女性和87.0%声称吸烟的女性（kappa=0.83）准确报告了她们的状态。在吸烟者中，可替宁浓度与每天吸烟数量之间的相关系数为0.44。血清可替宁浓度与婴儿出生体重的相关性比自我报告的吸烟情况更强（r=0.246 vs. 0.200）。总之，这项研究表明，孕妇准确地报告了他们是否吸烟，但可替宁浓度是一个更好的措施比自我报告的实际烟草剂量。
Although during pregnancy there is a better correlation between maternal serum cotinine concentration and adverse outcome than between self-reported smoking and such an outcome, few studies of pregnancy have measured cotinine concentration to determine how much a woman smokes. This study assessed the accuracy of self-reported smoking during pregnancy by performing serum cotinine assays on 448 women registered in the Collaborative Perinatal Project (1959-1966). Based on the assumption that a serum cotinine concentration of >10 ng/ml represented active smoking, 94.9% of women who denied smoking and 87.0% of women who stated that they smoked (kappa=0.83) reported their status accurately. Among smokers, the correlation coefficient between cotinine concentration and number of cigarettes smoked per day was 0.44. Serum cotinine concentration correlated more strongly than self-reported smoking with infant birth weight (r=0.246 vs. 0.200). In conclusion, this study showed that pregnant women accurately reported whether they smoked, but cotinine concentration was a better measure than self-report of the actual tobacco dose received.