Autonomic nervous system regulates secretion of anti-inflammatory prohormone SMR1 from rat salivary glands.
Autonomic nervous system regulates secretion of anti-inflammatory prohormone SMR1 from rat salivary glands.
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自主神经系统调节大鼠唾液腺抗炎激素原 SMR1 的分泌。
DOI：
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发表时间：
2009
期刊：
影响因子：
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通讯作者：
A. Befus
中科院分区：
文献类型：
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作者：
Katherine Morris;C. D. S. Laurent;R. S. Hoeve;Paul Forsythe;M. Suresh;Ronald D Mathison;A. Befus
自主神经系统调节来自唾液腺的生物活性蛋白和肽的分泌，这在全身生理反应中是重要的。在大鼠颌下腺中高表达的原激素大鼠-1可以裂解产生具有镇痛和抗炎活性的多肽。与下颌骨大鼠-1相关的人类基因具有保守的生物学功能，在疼痛抑制、勃起功能和炎症方面具有潜在的重要作用。在这项研究中，我们描述了雄性Sprague-Dawley和Brown Norway大鼠唾液腺、泌尿生殖道、肺、血液和唾液中下颌下rat-1蛋白的差异表达和翻译后修饰。下颌骨大鼠-1蛋白在肾上腺素能或胆碱能激动剂作用后分泌到唾液中。切除支配唾液腺的交感神经节可导致唾液腺下颌下大鼠-1蛋白水平升高。下颌骨大鼠-1在生理应激下的分泌可能提供大量的下颌骨大鼠-1衍生肽产物，可以促进局部和全身的镇痛和减少炎症。这种途径在哺乳动物中可能是保守的，并且可能构成对应激的重要抗炎和镇痛反应。
The autonomic nervous system regulates the secretion of bioactive proteins and peptides from salivary glands that can be important in systemic physiological responses. The prohormone submandibular rat-1, which is highly expressed in rat submandibular glands, can be cleaved to produce polypeptides with analgesic and anti-inflammatory activities. Human genes related to submandibular rat-1 have conserved biological functions and are potentially important in pain suppression, erectile function, and inflammation. In this study we describe the differential expression and posttranslational modification of submandibular rat-1 protein in salivary glands, the urogenital tract, lung, blood, and saliva in male Sprague-Dawley and Brown Norway rats. Submandibular rat-1 protein is secreted into saliva after the administration of beta-adrenergic or cholinergic agonists. Removal of the sympathetic ganglion that innervates the salivary glands results in increased levels of submandibular rat-1 protein in salivary glands. The secretion of submandibular rat-1 in response to physiological stress may provide a large pool of submandibular rat-1-derived peptide products that can promote analgesia and decrease inflammation locally and systemically. This pathway may be conserved among mammals and may constitute an important anti-inflammatory and analgesic response to stress.
hSMR3A 作为勃起功能障碍患者的标志物。
DOI：
10.1016/j.juro.2007.03.004
发表时间：
2007
期刊：
The Journal of urology
影响因子：
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作者：
Tong,Yuehong;Tar,Moses;Monrose,Val;DiSanto,Michael;Melman,Arnold;Davies,KelvinP
通讯作者：
Davies,KelvinP