ANEURYSM OF THE RABBIT COMMON CAROTID-ARTERY INDUCED BY PERIARTERIAL APPLICATION OF CALCIUM-CHLORIDE INVIVO
ANEURYSM OF THE RABBIT COMMON CAROTID-ARTERY INDUCED BY PERIARTERIAL APPLICATION OF CALCIUM-CHLORIDE INVIVO
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DOI：
10.1172/jci113368
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发表时间：
1988-03-01
影响因子：
15.9
通讯作者：
EISENBERG, D
中科院分区：
文献类型：
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作者：
GERTZ, SD;KURGAN, A;EISENBERG, D
在家兔颈总动脉周围注入氯化钙，引起动脉扩张。血管原位固定后3天，1周，3周，6周，12周的心内灌注戊二醛和组织制备的光，扫描和透射电镜。进行性局灶性动脉瘤性扩张仅限于应用钙的部位，在不规则管腔轮廓的区域内有内皮损伤和血栓形成。内膜和中膜的弹性网络破坏，可见不同程度的内膜纤维肌性增生和中膜解体。钙弹性组织复合体是炎症、动脉炎反应和随后的动脉瘤形成的焦点。炎性细胞浸润最初主要包括中性粒细胞，其次是淋巴细胞、浆细胞、单核细胞和多核巨细胞。这些研究支持了血管壁弹性组织网络的破坏是引起血管扩张的重要致病因素的假设。此外，这些研究的结果表明，钙与动脉壁的弹性膜的相互作用可能是一个重要的致病因素，在巨细胞动脉炎的启动。
Experimental aneurysmatic dilatation of the rabbit common carotid artery was induced by a single, periarterial application of calcium chloride in vivo. Vessels were fixed in situ after 3 d, 1 wk, 3 wk, 6 wk, and 12 wk by intracardiac perfusion of glutaraldehyde and tissues prepared for light, scanning, and transmission electron microscopy. Progressive focal aneurysmal dilatation was seen limited to the site of calcium application with endothelial damage and thrombus formation in areas of irregular luminal contour. Disruption of the elastic network of the intima and media was seen with varying degrees of intimal fibromuscular hyperplasia and medial disorganization. The calcium-elastic tissue complex was the focus of the inflammatory, arteriosclerotic reaction and subsequent aneurysm formation. The inflammatory cell infiltration initially included primarily neutrophils followed by lymphocytes, plasma cells, monocytes, and multinucleated giant cells. These studies support the hypothesis that disruption of the elastic tissue network of the vascular wall represents an important pathogenetic factor in the initiation of aneurysmal dilatation. In addition, the results of these studies suggest that interaction of calcium with the elastica of the arterial wall may represent an important pathogenetic factor in the initiation of giant cell arteritis.