Hippocampal volume and shape analysis in an older adult population
Hippocampal volume and shape analysis in an older adult population
复制标题
DOI：
10.1080/13854040601064534
复制
发表时间：
2007-01-01
影响因子：
3.9
通讯作者：
Shen, Li
中科院分区：
文献类型：
--
作者：
McHugh, Tara L.;Saykin, Andrew J.;Shen, Li
这份报告提出了一个手动分割协议的海马，产生一个可靠的与以前的可靠和全面的测量体积，一个目标，已被证明是可行的方法。该方法的主要特点包括在海马体的长轴中的图像的对齐和使用三维图像可视化功能来消除前后海马体边界的歧义。我们描述了海马体积和形状分析的程序，提供了评估者间和评估者内的可靠性数据，并检查了健康老年人样本中海马体积的相关性。参与者是40名健康的老年人，他们没有明显的认知障碍，没有轻度认知障碍或痴呆的证据，也没有其他神经或精神疾病。使用1.5 T GE Signa扫描仪，采集每位参与者的稳态（SPGR）序列三维扰相梯度回忆采集。图像）被重采样为1 mm各向同性体素，并在轴向和冠状平面中沿半球间裂沿着重新排列，在矢状平面中沿海马的长轴重新排列。使用BRAINS程序（Andreasen等人，1993）中，海马的边界在三个正交视图中过度可视化，并且边界分界线被转移到冠状平面用于追踪。在调整颅内体积（ICV）后计算海马体积。使用组内相关系数测量的评估者内和评估者间的可靠性，在左右海马体中都超过了0.94。后海马的总ICV调整体积为3.48（+/- 0.43）cc，右侧为3.68（+/- 0.42）cc。雄性和雌性之间海马体积无显著差异（p > 0.05）。除了提供一个全面的体积测量海马，包括在我们的跟踪协议允许分析海马形状的变化的改进。形状分析可能会产生新的信息，结构大脑的变化，在老龄化和痴呆症，不反映在体积测量单独。海马功能和功能障碍研究的这些和其他新方向将通过使用可靠，全面和一致的分割和测量方法来促进。
This report presents a manual segmentation protocol for the hippocampus that yields a reliable with prior reliable and comprehensive measure of volume, a goal that has proven doff methods. Key features of this method include alignment of the images in the long axis of the hippocampus and the use of a three-dimensional image visualization function to disambiguate anterior and posterior hippocampal boundaries. We describe procedures for hippocampal volumetry and shape analysis, provide inter- and intra-rater reliability data, and examine correlates of hippocampal volume in a sample of health), older adults. participants were 40 healthy, older adults with no significant cognitive complaints, no evidence of mild cognitive impairment or dementia, and no other neurological or psychiatric disorder. Using a 1.5 T GE Signa scanner, three-dimensional spoiled gradient recalled acquisition in a steady state (SPGR) sequences were acquired for each participant. Images)were resampled into I mm isotropic voxels, and realigned along the interhemispheric fissure in the axial and coronal planes, and the long axis of the hippocampus in the sagittal plane. Using the BRAINS program (Andreasen et al., 1993), the boundaries of the hippocampus over visualized in the three orthogonal vie)vs, and boundary demarcations were transferred to the coronal plane for tracing. Hippocampal volumes were calculated after adjusting for intracranial volume (ICV). Intra- and inter-rater reliabilities, measured using the intraclass correlation coefficient, exceeded .94 for both the left and right hippocampus. Total ICV-adjusted volumes were 3.48 (+/- 0.43) cc for the Aft hippocampus and 3.68 (+/- 0.42) for the right. There were no significant hippocampal volume differences between males and females (p > .05). In addition to providing a comprehensive volumetric measurement of the hippocampus, the refinements included in our tracing protocol permit analysis of changes in hippocampal shape. Shape analyses may yield novel information about structural brain changes in aging and dementia that are not reflected in volumetric measurements alone. These and other novel directions in research on hippocampal function and dysfunction will be facilitated by the use of reliable, comprehensive, and consistent segmentation and measurement methods.