Autophagy plays an important role in protecting Pacific oysters from OsHV-1 and Vibrio aestuarianus infections.
Autophagy plays an important role in protecting Pacific oysters from OsHV-1 and Vibrio aestuarianus infections.
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DOI：
10.1080/15548627.2015.1017188
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发表时间：
2015
期刊：
影响因子：
13.3
通讯作者：
Renault T
中科院分区：
文献类型：
--
作者：
Moreau P;Moreau K;Segarra A;Tourbiez D;Travers MA;Rubinsztein DC;Renault T
最近在世界各地爆发的太平洋牡蛎（长牡蛎）大规模死亡事件严重影响了水产养殖经济。虽然造成这些死亡暴发的原因似乎很复杂，但传染因子也参与其中。两种病原体与大规模死亡暴发有关，即1型卵巢疱疹病毒（OsHV-1）和河口弧菌。在这里，我们描述了这两种病原体与自噬之间的相互作用，自噬是一种保守的细胞内途径，在先天免疫中起着关键作用。我们首次证明了自噬途径在太平洋牡蛎中存在并发挥作用，并在保护动物免受感染方面发挥重要作用。这项研究有助于更好地了解太平洋牡蛎的先天免疫系统。
Recent mass mortality outbreaks around the world in Pacific oysters, Crassostrea gigas, have seriously affected the aquaculture economy. Although the causes for these mortality outbreaks appear complex, infectious agents are involved. Two pathogens are associated with mass mortality outbreaks, the virus ostreid herpesvirus 1 (OsHV-1) and the bacterium Vibrio aestuarianus. Here we describe the interactions between these 2 pathogens and autophagy, a conserved intracellular pathway playing a key role in innate immunity. We show for the first time that autophagy pathway is present and functional in Pacific oysters and plays an important role to protect animals from infections. This study contributes to better understand the innate immune system of Pacific oysters.