Glutathione S-transferase and glutathione reductase activities in hepatic and extrahepatic tissues of female mice as a function of age.
Glutathione S-transferase and glutathione reductase activities in hepatic and extrahepatic tissues of female mice as a function of age.
复制标题
雌性小鼠肝脏和肝外组织中的谷胱甘肽 S-转移酶和谷胱甘肽还原酶活性与年龄的关系。
DOI：
10.1016/0006-2952(82)90429-4
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发表时间：
1982
影响因子：
5.8
通讯作者：
C. Angle
中科院分区：
文献类型：
--
作者：
S. Stohs;W. A. A;C. Angle
短玉米免疫 2113 阻断由其他促分泌剂（例如化合物 48/80、离子载体 A23187、多粘菌素 B 和 ATP）诱导的肥大细胞释放组胺。 3-Deaza-SIBA 可能通过胆碱掺入抑制磷脂酰胆碱的生物合成，从而干扰嗜碱性白血病细胞和肥大细胞的膜功能，而胆碱掺入可能是细胞脱粒和组胺释放所必需的。先前对 3-deaza-SIBA 的研究主要是根据其与 S-腺苷高半胱氨酸的结构相似性及其作为甲基化反应抑制剂的潜在用途来解释的。根据我们目前的发现，必须仔细解释利用 3-deaza-SIBA 作为生化探针的实验。
Short Corn lmunications 2113 blocked the histamine release from mast cells induced by other secretagogues, such as compound 48/80, ionophore A23187, polymyxin B and ATP. 3-Deaza-SIBA may perturb membrane functions of basophilic leukemia cells and mast cells by inhibiting the biosynthesis of phosphatidylcholine via choline incorporation, the turnover of which is probably required for cellular degranulation and the release of histamine. Previous studies with 3-deaza-SIBA have been mainly interpreted in terms of its structural similarity to S-adenosylhomocysteine and its potential use as an inhibitor of methylation reactions. In light of our present findings, experiments utilizing 3-deaza-SIBA as a biochemical probe have to be carefully interpreted.