Role of cecal pH in intestinal oxalate absorption in the rat
Role of cecal pH in intestinal oxalate absorption in the rat
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发表时间：
1988-09
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通讯作者：
Diamond Kl;Fox Cc
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作者：
Diamond Kl;Fox Cc
高尿症发生于许多胃肠道疾病，并伴有吸收不良。这种高尿酸血症是结肠对饮食中草酸盐吸收增加的结果。这种影响的机制包括粪便脂肪酸的改变，粪便胆汁酸的改变，和酸化的结肠pH值。使用乳果糖诱导的慢性结肠酸化的动物模型，我们研究了体内草酸盐吸收的pH值的影响。每天给大鼠喂食含6.77 mg草酸盐的饮食，含和不含乳果糖。接受乳果糖的动物的盲肠pH值显著低于对照组（4.90 +/- 0.42 vs 7.17 +/- 0.38; p <0.001）。接受乳果糖饮食的动物的草酸盐尿排泄量显著高于对照组（0.975 +/- 0.144 vs 0.844 +/- 0.172 mg草酸盐/天; p <0.001）。这些结果表明，结肠酸化导致尿草酸排泄显著增加。因此，结肠酸化可能是肠型高尿酸血症发病机制中的一个重要因素。
Hyperoxaluria occurs with many gastrointestinal disorders complicated by malabsorption. This hyperoxaluria is known to be the result of increased colonic absorption of dietary oxalate. Proposed mechanisms for this effect include alterations in fecal fatty acids, alterations in fecal bile acids, and acidification of colonic pH. Using an animal model of lactulose-induced chronic colonic acidification, we examined the effect of pH on oxalate absorption in vivo. Rats were fed a diet containing 6.77 mg oxalate per day with and without lactulose. Cecal pH of the animals receiving lactulose was significantly lower than controls (4.90 +/- 0.42 vs 7.17 +/- 0.38; p less than 0.001). Urinary excretion of oxalate was significantly greater in animals receiving the lactulose diet than in controls (0.975 +/- 0.144 vs 0.844 +/- 0.172 mg oxalate per day; p less than 0.001). These results demonstrate that acidification of the colon results in a significant increase in urinary oxalate excretion. Thus, acidification of the colon may be an important factor in the pathogenesis of enteric hyperoxaluria.