Gravidity-dependent production of antibodies that inhibit binding of Plasmodium falciparum-infected erythrocytes to placental chondroitin sulfate proteoglycan during pregnancy
Gravidity-dependent production of antibodies that inhibit binding of Plasmodium falciparum-infected erythrocytes to placental chondroitin sulfate proteoglycan during pregnancy
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DOI：
10.1128/iai.69.12.7487-7492.2001
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发表时间：
2001-12-01
影响因子：
3.1
通讯作者：
Gowda, DC
中科院分区：
文献类型：
--
作者：
O'Neil-Dunne, I;Achur, RN;Gowda, DC
在怀孕期间，恶性疟原虫感染的红细胞通过粘附于4-硫酸软骨素而隔离在胎盘中，对母亲和胎儿都产生了风险因素。经产妇感染胎盘型疟疾的风险高于经产妇。这种易感性的差异是由于缺乏抗体，阻断感染的红细胞粘附到胎盘软骨素4-硫酸在早孕妇女。然而，最近的研究结果表明，在长期的许多孕妇的抗体水平相似的multigravidae，因此，在怀孕期间提供保护，防止疟疾的抗粘附抗体的意义仍然不清楚。在这项研究中，我们分析了不同妊娠期不同妊娠妇女的血浆样本中的抗粘附抗体。大多数妇女，无论怀孕与否，在足月时抗体水平相似。大多数孕妇在怀孕20周之前有低水平的抗粘附抗体或没有抗粘附抗体，然后产生抗体。Multigravidae也缺乏抗体，直到怀孕12周，但此后他们有效地产生抗体。在足月时有胎盘感染的孕妇中，较高水平的抗粘附抗体与较低水平的胎盘寄生虫血症相关。在动力学的抗体生产之间的差异，plastugraidae和multigravidae与疟疾的患病率在这些群体，表明抗体在妊娠期间产生的胎盘感染。早期发病的有效抗体反应在multigravidae和延迟生产的抗体在plasgravidae似乎占孕妇的妊娠依赖性的差异易感性胎盘疟疾。
During pregnancy, Plasmodium falciparum-infected erythrocytes sequester in the placenta by adhering to chondroitin 4-sulfate, creating a risk factor for both the mother and the fetus. The primigravidae are at higher risk for placental malaria than the multigravidae. This difference in susceptibility has been attributed to the lack of antibodies that block the adhesion of infected erythrocytes to placental chondroitin 4-sulfate in primigravid women. However, recent results show that many primigravidae at term have antibody levels similar to those of multigravidae, and thus the significance of antiadhesion antibodies in providing protection against malaria during pregnancy remains unclear. In this study, we analyzed plasma samples from women of various gravidities at different gestational stages for antiadhesion antibodies. The majority of women, regardless of gravidity, had similar levels of antibodies at term. Most primigravidae had low levels of or no antiadhesion antibodies prior to similar to 20 weeks of pregnancy and then produced antibodies. Multigravidae also lacked antibodies until similar to 12 weeks of pregnancy, but thereafter they efficiently produced antibodies. In pregnant women who had placental infection at term, higher levels of antiadhesion antibodies correlated with lower levels of placental parasitemia. The difference in kinetics of antibody production between primigravidae and multigravidae correlated with the prevalence of malaria in these groups, suggesting that antibodies are produced during pregnancy in response to placental infection. The early onset of efficient antibody response in multigravidae and the delayed production to antibodies in primigravidae appear to account for the gravidity-dependent differential susceptibilities of pregnant women to placental malaria.