Long-term prognosis in hepatocellular carcinoma patients after hepatectomy.
Long-term prognosis in hepatocellular carcinoma patients after hepatectomy.
复制标题
肝切除术后肝细胞癌患者的长期预后。
DOI：
10.7314/apjcp.2012.13.2.483
复制
发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Ruitao Wang
中科院分区：
文献类型：
--
作者：
Lei Zhou;Chang Liu;Fandi Meng;K. Qu;F. Tian;Ming;Ji;Ruitao Wang
背景
肝细胞癌是我国常见的恶性肿瘤之一。本报告的目的是根据目前十年的资料，调查可能影响肝细胞癌患者肝切除术后预后的临床和病理因素。
方法
在2002年至2009年期间，对所有接受肝切除术的HCC患者进行了随访和回顾性分析。采用Kaplan-Meier和考克斯多因素生存分析进行单因素和多因素分析。
结果
完整的临床病理和随访数据可用于114例患者。1年、3年和5年的估计累积生存率分别为84.6%、60.2%和51.8%。单因素分析显示，影响预后的主要因素为AFP、GGT水平、肿瘤大小、肿瘤数目、门静脉侵犯、肝硬化程度和TNM分期。多因素分析中，肿瘤大小、GGT水平、肝硬化程度、门静脉侵犯与患者预后显著相关。
结论
通过对一个相对较大的中国患者队列的随访，发现肿瘤大小、GGT水平、肝硬化状态、门静脉侵犯是肝切除术后长期生存的重要因素。肿瘤的早期诊断和术前肝功能的改善是改善预后的重要途径。
BACKGROUND
The hepatocellular carcinoma is very common in China. Our aim in this report was to investigate clinical and pathological factors based on the current decade data that could influence prognosis of HCC patients after hepatectomy.
METHODS
Between 2002 and 2009, all patients undergoing hepatectomy for HCC were followed up and reviewed retrospectively. Prognostic factors were studied by univariate and multivariate analysis, with Kaplan-Meier and Cox multivariate survival analyses.
RESULTS
Complete clinicopathologic and follow-up data were available for 114 patients. The estimated cumulative survival rates at 1, 3, and 5 yr were 84.6%, 60.2% and 51.8%, respectively. On univariate analysis, key prognostic factors were AFP level, GGT level, tumor size, number of tumors, portal vein invasion, liver cirrhosis status and TNM stage. In the multivariate analysis, tumor size, GGT level, liver cirrhosis status and portal vein invasion were significantly associated with patients' prognosis.
CONCLUSION
Through follow-up of a relatively large cohort of Chinese patients, tumor size, GGT level, liver cirrhosis status, portal vein invasion were revealed as important factors for long-term survival after hepatectomy. Early diagnosis for tumor and the improvement of liver function before surgery are important ways to improve the prognosis.
影响因子：
4.6
作者：
Pawlik, TM;Delman, KA;Abdalla, EK
通讯作者：
Abdalla, EK