The emerging therapeutic potential of extracellular vesicles in trauma.
The emerging therapeutic potential of extracellular vesicles in trauma.
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DOI：
10.1002/jlb.3mir0621-298r
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发表时间：
2022-01
影响因子：
5.5
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中科院分区：
文献类型：
--
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创伤性损伤是世界范围内发病率和死亡率的主要原因，尽管在治疗方面取得了重大进展。大多数死亡发生在非常早期，通过大面积头部创伤/CNS损伤或失血（尽管输血医学取得了进展），或在损伤后较晚，通常通过多器官衰竭和继发感染。已知细胞外囊泡（EV）在创伤后循环中增加，并且已在有限程度上用作诊断和预后标记物。更有趣的是，EV现在正在被研究作为创伤后病理学的原因，如创伤诱导的凝血病，以及作为潜在的治疗方法。在这篇综述中，我们强调了目前已知的EV在创伤的各个方面的作用和影响，以及探索目前的文献，从研究人员谁已经开始使用EV治疗改变创伤性损伤的生理和病理。大量的实验研究支持了在创伤治疗中使用电动汽车的潜在有效性，但在我们了解电动汽车在已经是复杂的疾病过程中的复杂影响之前，还有一段路要走。
Traumatic injury is a major cause of morbidity and mortality worldwide, despite significant advances in treatments. Most deaths occur either very early, through massive head trauma/CNS injury or exsanguination (despite advances in transfusion medicine), or later after injury often through multiple organ failure and secondary infection. Extracellular vesicles (EVs) are known to increase in the circulation after trauma and have been used to limited extent as diagnostic and prognostic markers. More intriguingly, EVs are now being investigated as both causes of pathologies post trauma, such as trauma-induced coagulopathy, and as potential treatments. In this review, we highlight what is currently known about the role and effects of EVs in various aspects of trauma, as well as exploring current literature from investigators who have begun to use EVs therapeutically to alter the physiology and pathology of traumatic insults. The potential effectiveness of using EVs therapeutically in trauma is supported by a large number of experimental studies, but there is still some way to go before we understand the complex effects of EVs in what is already a complex disease process.