Mechanisms of carbon nanotube-induced toxicity: focus on oxidative stress.
Mechanisms of carbon nanotube-induced toxicity: focus on oxidative stress.
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DOI：
10.1016/j.taap.2012.03.023
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发表时间：
2012-06-01
影响因子：
3.8
通讯作者：
Kagan VE
中科院分区：
文献类型：
--
作者：
Shvedova AA;Pietroiusti A;Fadeel B;Kagan VE
纳米技术正在成为社会许多部门非常有前途的技术。然而，越来越多地使用工程纳米材料也引起了人们对无意中接触这些材料以及对人类健康和环境可能产生不利影响的担忧。尽管经过几年的深入研究，理解纳米颗粒诱导毒性的共同范式仍有待牢固建立。在这里，所谓的氧化应激范式是仔细检查。氧化应激是生化过程破坏和细胞死亡不可避免地导致的继发性事件，还是在诱导细胞损伤（如凋亡）中起作用的特定、非随机事件？这个问题的答案将对减轻纳米颗粒不良影响的策略的发展产生重要影响。全球脂质组学研究的纳米颗粒诱导的组织损伤的最新例子进行了讨论沿着与蛋白质组学和转录组学的方法，以实现一个全面的了解复杂的和相互关联的分子变化的细胞和组织暴露于纳米颗粒。我们还讨论了非氧化应激介导的细胞损伤的纳米材料与细胞结构的直接物理干扰所造成的情况。
Nanotechnologies are emerging as highly promising technologies in many sectors in the society. However, the increasing use of engineered nanomaterials also raises concerns about inadvertent exposure to these materials and the potential for adverse effects on human health and the environment. Despite several years of intensive investigations, a common paradigm for the understanding of nanoparticle-induced toxicity remains to be firmly established. Here, the so-called oxidative stress paradigm is scrutinized. Does oxidative stress represent a secondary event resulting inevitably from disruption of biochemical processes and the demise of the cell, or a specific, non-random event that plays a role in the induction of cellular damage e.g. apoptosis? The answer to this question will have important ramifications for the development of strategies for mitigation of adverse effects of nanoparticles. Recent examples of global lipidomics studies of nanoparticle-induced tissue damage are discussed along with proteomics and transcriptomics approaches to achieve a comprehensive understanding of the complex and interrelated molecular changes in cells and tissues exposed to nanoparticles. We also discuss instances of non-oxidative stress-mediated cellular damage resulting from direct physical interference of nanomaterials with cellular structures.