The Combination of Aricept with a Traditional Chinese Medicine Formula, Smart Soup, May Be a Novel Way to Treat Alzheimer's Disease
The Combination of Aricept with a Traditional Chinese Medicine Formula, Smart Soup, May Be a Novel Way to Treat Alzheimer's Disease
复制标题
DOI：
10.3233/jad-143183
复制
发表时间：
2015-01-01
影响因子：
4
通讯作者：
Ding, Jianqing
中科院分区：
文献类型：
--
作者：
Wang, Ying;Wang, Ying;Ding, Jianqing
阿尔茨海默病（Alzheimer's disease，AD）是一种常见的影响老年人认知功能的神经退行性疾病，其特征在于存在不溶性淀粉样蛋白-β斑块的细胞外沉积和神经元损失。现代药理学和药物开发通常遵循单靶点原则，这可能导致大多数化合物在抗AD临床试验中失败。考虑到AD是一种多因素疾病，应用具有不同机制的药物的联合治疗策略将是一种替代方法。聪明汤（SS）是一种传统的中药配方，由三种草本植物组成，在中国已被应用于治疗健忘症数百年。在这项工作中，我们研究了SS和安理申组合在AD治疗中的临床效力。在体内模型中，联合用药组AD转基因果蝇的寿命和运动能力均显著提高。我们还观察到联合药物治疗后淀粉样β蛋白沉积减少和神经元丢失延迟。在回顾性队列研究中，我们发现联合治疗对AD患者有更好的治疗效果。我们的研究表明，多个药物靶点的联合治疗确实有更好的治疗效果。这为开发抗AD的最佳药物途径提供了新的策略。
Alzheimer's disease (AD) is a common neurodegenerative disease affecting cognitive function in the elderly, which is characterized by the presence of extracellular deposits of insoluble amyloid-beta plaques and neuronal loss. Modern pharmacology and drug development usually follow a single-target principle, which might contribute to the failure of most compounds in clinical trials against AD. Considering AD is a multifactorial disease, a combination therapeutic strategy that applies drugs with different mechanisms would be an alternative way. Smart Soup (SS), a Traditional Chinese Medicine formula, is composed of three herbaceous plants and has been applied in the treatment of amnesia in China for hundreds of years. In this work, we studied the clinical potency of the combination of SS and Aricept in AD therapy. In the in vivo model, both longevity and locomotive activity of AD transgenic Drosophila were improved remarkably in the combined medicine treated group. We also observed less amyloid-beta deposition and retarded neuronal loss following the combined drug treatment. In the retrospective cohort study, we found the combination therapy exerted better therapeutic effect on AD patients. Our study revealed that combination therapy with multiple drug targets did have a better therapeutic outcome. It provides a new strategy to develop an optimum pharmaceutical approach against AD.