Lack of Impact of Mild Obstructive Sleep Apnea on Sleepiness, Mood and Quality of Life.
Lack of Impact of Mild Obstructive Sleep Apnea on Sleepiness, Mood and Quality of Life.
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DOI：
10.13175/swjpcc082-14
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发表时间：
2014
影响因子：
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通讯作者：
Kushida CA
中科院分区：
文献类型：
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作者：
Quan SF;Budhiraja R;Batool-Anwar S;Gottlieb DJ;Eichling P;Patel S;Shen W;Walsh JK;Kushida CA
阻塞性睡眠呼吸暂停（OSA）与嗜睡、抑郁和生活质量下降有关。然而，目前尚不清楚轻度OSA是否具有这些负面影响。使用来自呼吸暂停正压长期疗效研究（APPLES）的数据，该研究确定了轻度OSA的参与者与没有OSA的参与者相比是否有更大的嗜睡，更多的抑郁症状和更差的生活质量。239名基线呼吸暂停低通气指数（AHI）< 15 /小时的参与APPLES评估的个体被分配到2组中的一组：基于他们的筛选多导睡眠图，无OSA（N=40，AHI < 5 /小时）或轻度OSA（N=199，5至<15 /小时）。比较两组患者的埃普沃思嗜睡量表（ESS）、斯坦福大学嗜睡量表（SSS）、汉密尔顿抑郁量表（HAM-D）、心境状态量表（POMS）和睡眠呼吸暂停生活质量指数（SAQLI）评分。无OSA组和轻度OSA组之间在5项指标中的任何一项上均无显著差异：ESS（无OSA，9.8 ± 3.5 vs轻度OSA，10.6 ± 4.3，p=0.26），SSS，（2.8 ± 0.9 vs. 2.9 ± 1.0，p=0.52），HAM-D（4.6 ± 3.0 vs. 4.9 ± 4.7，p=0.27），POMS（33.5 ± 22.3 vs. 28.7 ± 22.0，p=0.70），SAQLI（4.5 ± 0.8 vs. 4.7 ± 0.7，p=0.39）。与没有OSA的人相比，这个队列中轻度OSA的人没有更差的嗜睡，情绪或生活质量。
Obstructive sleep apnea (OSA) is associated with sleepiness, depression and reduced quality of life. However, it is unclear whether mild OSA has these negative impacts. Using data from the Apnea Positive Pressure Long-term Efficacy Study (APPLES), this study determined whether participants with mild OSA had greater sleepiness, more depressive symptoms and poorer quality of life in comparison to those without OSA. 239 individuals evaluated for participation in APPLES with a baseline apnea hypopnea index (AHI) < 15 /hour were assigned to 1 of 2 groups: No OSA (N=40, AHI < 5 /hour) or Mild OSA (N=199, 5 to <15 /hour) based on their screening polysomnogram. Scores on their Epworth Sleepiness Scale (ESS), Stanford Sleepiness Scale (SSS), Hamilton Rating Scale for Depression (HAM-D), Profile of Mood States (POMS) and Sleep Apnea Quality of Life Index (SAQLI) were compared between groups. There were no significant differences between the No OSA and Mild OSA groups on any of the 5 measures: ESS (No OSA, 9.8 ± 3.5 vs Mild OSA, 10.6 ± 4.3, p=0.26), SSS,(2.8 ± 0.9 vs. 2.9 ± 1.0, p=0.52), HAM-D (4.6 ± 3.0 vs. 4.9 ± 4.7, p=0.27), POMS (33.5 ± 22.3 vs. 28.7 ± 22.0, p=0.70), SAQLI (4.5 ± 0.8 vs. 4.7 ± 0.7, p=0.39). Individuals with mild OSA in this cohort do not have worse sleepiness, mood or quality of life in comparison to those without OSA.