Cortical sensory plasticity in a model of migraine with aura.
Cortical sensory plasticity in a model of migraine with aura.
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DOI：
10.1523/jneurosci.2092-12.2012
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发表时间：
2012-10-31
期刊：
影响因子：
--
通讯作者：
Brennan KC
中科院分区：
文献类型：
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作者：
Theriot JJ;Toga AW;Prakash N;Ju YS;Brennan KC
偏头痛发作的特征是感官知觉的改变，如畏光或超敏，这些共同之处是感觉不舒服的放大。目前尚不清楚这些变化是如何产生的。我们评估了皮层扩散抑制(CSD)的能力，该机制被认为是偏头痛先兆的机制，它塑造了构成感觉知觉的皮质活动。我们使用多电极阵列记录和二维光学光谱技术，测量了CSD前后大鼠的前爪和后爪诱发的感觉反应。CSD在与偏头痛发作持续时间相适应的时间尺度上显著改变了皮质感觉处理。CSD术后电生理和血流动力学地形图的表面积均缩小(锐化)。电生理反应在感受野中心被增强，而在周围区域被抑制。最后，感觉诱发反应的正常适应在感受野中心减弱。综上所述，我们证明了CSD引起的皮质反应的改变与已知的皮质可塑性机制是一致的。这些机制提供了一种新的神经生物学底物来解释偏头痛发作的感觉变化。
The migraine attack is characterized by alterations in sensory perception, such as photophobia or allodynia, which have in common an uncomfortable amplification of the percept. It is not known how these changes arise. We evaluated the ability of cortical spreading depression (CSD), the proposed mechanism of the migraine aura, to shape the cortical activity that underlies sensory perception. We measured forepaw- and hindpaw-evoked sensory responses in rat, before and after CSD, using multi-electrode array recordings and 2-dimensional optical spectroscopy. CSD significantly altered cortical sensory processing on a timescale compatible with the duration of the migraine attack. Both electrophysiological and hemodynamic maps had a reduced surface area (were sharpened) after CSD. Electrophysiological responses were potentiated at the receptive field center, but suppressed in surround regions. Finally, the normal adaptation of sensory evoked responses was attenuated at the receptive field center. In summary, we show that CSD induces changes in the evoked cortical response that are consistent with known mechanisms of cortical plasticity. These mechanisms provide a novel neurobiological substrate to explain the sensory alterations of the migraine attack.