PROJECTIONS FROM NUCLEUS OF SOLITARY TRACT IN RAT
PROJECTIONS FROM NUCLEUS OF SOLITARY TRACT IN RAT
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DOI：
10.1016/0306-4522(78)90102-1
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发表时间：
1978-01-01
期刊：
影响因子：
3.3
通讯作者：
NORGREN, R
中科院分区：
文献类型：
--
作者：
NORGREN, R
用氨基酸滴定放射自显影法观察孤束核内及附近神经元的轴突投射。这个核的神经元轴突在核本身内广泛分支，但在连合核中分支较少。它们也进入延髓内的颅运动核。起源于孤束核前部的轴突延伸到舌下神经、面神经和可能的三叉神经运动核，但不延伸到迷走神经背侧运动核或疑核。孤束核的后部投射到所有这些运动核。在脊髓中，孤束核轴突保留在孤束核本身直接尾侧的内侧灰质中。在三叉神经尾侧核内有纤维向外侧扩展后，到C3时，这种分布变得很弱。纤维标记在对侧腹侧列，但他们不能明确地归因于孤立的神经元。从孤束核上行的轴突延伸到脑桥，在那里它们终止于臂旁核的尾端。虽然经常被视为完全独立的系统，目前的研究结果表明，次级味觉神经元在前孤核和次级内脏传入神经元在后孤核有非常相似的吻侧和尾侧的预测。桥臂旁核是孤核神经元的吻侧末端，与丘脑、下丘脑和边缘前脑有广泛的直接联系。假设类似的连接发生在其他哺乳动物中，这些发现建立了双突触内脏传入进入大脑中最高自主整合中心的存在。
The axonal projections of neurons in and near the nucleus of the solitary tract were visualized using titrated amino acid autoradiography. Axons of neurons of this nucleus ramify extensively within the nucleus itself, but much less so in the nucleus commissuralis. They also enter cranial motor nuclei within the medulla. Axons originating in the anterior part of the nucleus of the solitary tract extend to the hypoglossal, facial and probably trigeminal motor nuclei, but not to the dorsal motor nucleus of the vagus or the nucleus ambiguus. The posterior part of the nucleus of the solitary tract projects to all these motor nuclei. In the spinal cord, solitary nucleus axons remain in the medial gray directly caudal to the solitary nucleus itself. The distribution becomes very weak by C3 after some fibers spread laterally into the caudal trigeminal nucleus. Fibers are labeled in the contralateral ventral columns, but they could not be unequivocably attributed to solitary neurons. Axons ascending from the nucleus of the solitary tract extend no further rostrally than the pons, where they terminate in the caudal end of the parabrachial nuclei. Although often treated as entirely separate systems, the present results indicate that secondary gustatory neurons in the anterior solitary nucleus and secondary visceral afferent neurons in the posterior solitary nucleus have very similar rostral and caudal projections. The pontine parabrachial nuclei, the rostral termination of solitary nucleus neurons, have extensive direct connections to the thalamus, the hypothalamus and the limbic forebrain. Assuming similar connections occur in other mammals, these findings establish the existence of di-synaptic visceral afferent access to the highest autonomic integrative centers in the brain.