Clinical progression of patients with COVID-19 in Shanghai, China
Clinical progression of patients with COVID-19 in Shanghai, China
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DOI：
10.1016/j.jinf.2020.03.004
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发表时间：
2020-05-01
影响因子：
28.2
通讯作者：
Lu, Hongzhou
中科院分区：
文献类型：
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作者：
Chen, Jun;Qi, Tangkai;Lu, Hongzhou
背景：对2019年新型冠状病毒病(新冠肺炎)的研究一般局限于对其流行病学和初步临床特征的描述。方法：在这项单中心的回顾性研究中，我们纳入了2020年1月20日至2月6日在上海确诊的新冠肺炎病例。结果：249例患者中，中位年龄51岁，男性126例(50.6%)。有症状的患者从出现症状到住院时间为4(2-7)天。235例(94.3%)出现发热。共有215例(86.3%)患者在住院16天(12-20天)后出院。所有发热患者的中位发热持续时间估计为症状出现后10天(95个机密间隔：8-11天)。转至重症监护病房(ICU)的患者与未转至ICU的患者相比，发热持续时间明显延长(分别为出现症状后31天和9天，P
Background: Studies on the 2019 novel coronavirus disease (COVID-19) have generally been limited to the description of the epidemiology and initial clinical characteristics. We investigated the temporal progression in patients with COVID-19.Methods: In this retrospective, single-center study, we included confirmed cases of COVID-19 from Jan 20 to Feb 6, 2020 in Shanghai. Final date of follow-up was February 25, 2020.Results: Of the 249 patients enrolled, the median age was 51 years old, and 126 (50.6%) were male. The duration from onset of symptoms to hospitalization was 4(2-7) days in symptomatic patients. Fever was occurred in 235(94.3%) patients. A total of 215 (86.3%) patients had been discharged after 16(12-20) days hospitalization. The estimated median duration of fever in all the patients with fever was 10 days (95 confidential intervals [CIs]: 8-11 days) after onset of symptoms. Patients who were transferred to intensive care units (ICU) had significantly longer duration of fever as compared to those not in ICU (31 days v.s. 9 days after onset of symptoms, respectively, P