Elevation of serum epidermal growth factor and interleukin 1 receptor antagonist in active psoriasis vulgaris
Elevation of serum epidermal growth factor and interleukin 1 receptor antagonist in active psoriasis vulgaris
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DOI：
10.1111/j.1365-2133.2010.09990.x
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发表时间：
2010-11-01
影响因子：
10.3
通讯作者：
Enerback, C.
中科院分区：
文献类型：
--
作者：
Anderson, K. S.;Petersson, S.;Enerback, C.
银屑病斑块呈现复杂的表达谱，包括高水平的细胞因子、趋化因子和生长因子。循环细胞因子被认为反映炎症过程的激活状态。目的分析14例寻常型银屑病患者紫外线B治疗初期及治疗过程中20种细胞因子、趋化因子及生长因子的变化。方法采用多重细胞因子试验。结果：与对照组相比，银屑病患者血清中表皮生长因子（EGF）（平均323比36.6 pg mL(-1), P = 0.0001）、白细胞介素(IL)-1受体拮抗剂（平均391比14.6 pg mL(-1), P = 0.02）和肿瘤坏死因子- α（平均7.5比4.5 pg mL(-1), P = 0.04）的基线水平均有所升高。这些细胞因子均与疾病的严重程度（银屑病面积和严重程度指数）无关，也与光疗相关，表明病变皮肤以外的其他来源有助于这些细胞因子的产生。通过聚类分析，我们观察到EGF、IL-6、巨噬细胞炎症蛋白-1 β和血管内皮生长因子的协同上调。结论炎症循环细胞因子的持续高表达是银屑病及其皮外合并症的潜在机制。
Background Psoriatic plaques present a complex expression profile, including high levels of cytokines, chemokines and growth factors. Circulating cytokines have been suggested to reflect the activation status of the inflammatory process. Objectives To analyse 20 cytokines, chemokines and growth factors in 14 patients with psoriasis vulgaris at the start and during the course of ultraviolet B treatment.Methods A multiplex cytokine assay was used.Results We identified increased serum levels of epidermal growth factor (EGF) (mean 323 vs. 36 6 pg mL(-1), P = 0 0001), interleukin (IL)-1 receptor antagonist (mean 39 1 vs. 14 6 pg mL(-1), P = 0 02) and tumour necrosis factor-alpha (mean 7 5 vs. 4 5 pg mL(-1), P = 0 04) at baseline in patients with psoriasis compared with matched controls. None of these cytokines was correlated to the severity of the disease (Psoriasis Area and Severity Index) or decreased with phototherapy, suggesting that sources other than lesional skin contribute to the production of these cytokines. Using cluster analysis, we observed coordinate upregulation of EGF, IL-6, macrophage inflammatory protein-1 beta and vascular endothelial growth factor.Conclusions The sustained high expression of inflammatory circulating cytokines is a potential mechanism linking psoriasis with its extracutaneous comorbidities.