Female Drosophila melanogaster Gene Expression and Mate Choice: The X Chromosome Harbours Candidate Genes Underlying Sexual Isolation
Female Drosophila melanogaster Gene Expression and Mate Choice: The X Chromosome Harbours Candidate Genes Underlying Sexual Isolation
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DOI：
10.1371/journal.pone.0017358
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发表时间：
2011-02-28
期刊：
影响因子：
3.7
通讯作者：
Qvarnstrom, Anna
中科院分区：
文献类型：
--
作者：
Bailey, Richard I.;Innocenti, Paolo;Qvarnstrom, Anna
背景：在物种形成的早期阶段，雌性偏爱同类雄性的选择机制的进化被认为是至关重要的一步。然而，尽管配偶选择的基因组学可能会影响物种形成的可能性和速度，但选择性交配的基因的身份和位置在很大程度上仍然未知。方法与发现：利用雌性黑腹果蝇的配偶选择实验和基因表达分析，研究了影响物种形成的三个关键因素。我们发现，在与更多（津巴布韦）和更少（世界菌株）偏好的雄性交配时，津巴布韦雌性D. melanogaster的1498个基因的表达水平不同，包括许多在中枢神经系统和卵巢中高表达的基因，不成比例的x连锁，并形成了一些低重组距离的集群。大脑和卵巢的显著参与与交配前和交配后雌性选择机制的联合作用是一致的，而性别联系和基因聚类导致了高潜在的进化速率，并保护了种群间基因交换的均质化效应。结论：综上所述，我们的研究结果表明，通过配偶选择，津巴布韦黑腹龙的生殖隔离进化具有有利的基因组条件，并且表明配偶选择可能在物种形成中起着比以前认识到的更重要的推动作用。
Background: The evolution of female choice mechanisms favouring males of their own kind is considered a crucial step during the early stages of speciation. However, although the genomics of mate choice may influence both the likelihood and speed of speciation, the identity and location of genes underlying assortative mating remain largely unknown.Methods and Findings: We used mate choice experiments and gene expression analysis of female Drosophila melanogaster to examine three key components influencing speciation. We show that the 1,498 genes in Zimbabwean female D. melanogaster whose expression levels differ when mating with more (Zimbabwean) versus less (Cosmopolitan strain) preferred males include many with high expression in the central nervous system and ovaries, are disproportionately X-linked and form a number of clusters with low recombination distance. Significant involvement of the brain and ovaries is consistent with the action of a combination of pre- and postcopulatory female choice mechanisms, while sex linkage and clustering of genes lead to high potential evolutionary rate and sheltering against the homogenizing effects of gene exchange between populations.Conclusion: Taken together our results imply favourable genomic conditions for the evolution of reproductive isolation through mate choice in Zimbabwean D. melanogaster and suggest that mate choice may, in general, act as an even more important engine of speciation than previously realized.