Relationships of Retinal Structure and Humphrey 24-2 Visual Field Thresholds in Patients With Glaucoma
Relationships of Retinal Structure and Humphrey 24-2 Visual Field Thresholds in Patients With Glaucoma
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DOI：
10.1167/iovs.14-15885
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发表时间：
2015-01-01
影响因子：
4.4
通讯作者：
Abramoff, Michael D.
中科院分区：
文献类型：
--
作者：
Bogunovic, Hrvoje;Kwon, Young H.;Abramoff, Michael D.
目的.目的：探讨在开角型青光眼各期中，视网膜神经节细胞-轴突复合体（RGC-AC）局部损伤与Humphrey 24-2视野各部位视觉阈值之间的关系。从三级青光眼诊所招募早期、中度和晚期青光眼患者。对每例受试者采集Humphrey 24-2和9场Spectralis SD-OCT。将各个OCT体积对齐，神经纤维层（NFL）、神经节细胞和内丛状层（GCL+IPL）共分段。然后将这些层划分为对应于24-2网格的54个扇区。使用这些结构属性，为每个扇区独立训练支持向量机以预测扇区阈值。122例连续受试者，43例早期、39例中度和40例晚期青光眼被纳入（122只眼）。平均相关系数（R）为0.68（0.47-0.82），平均均方根误差（RMSE）为6.92 dB（3.93-8.68 dB）。整个视野、上级半视野和下级半视野的平均预测性能的R（RMSE）值分别为0.77（3.76）、0.80（5.05）和0.84（3.80）dB。使用RGC-AC概念，从来自九场SD-OCT局部NFL和GCL+IPL厚度的结构信息预测个体24-2视野阈值是可行的，显示了SD-OCT结构信息对视觉功能的预测能力的潜力。最终，通过OCT客观预测功能，补充和减轻青光眼患者主观视野检查的负担可能是可行的。
PURPOSE. To determine relationships between spectral-domain optical coherence tomography (SD-OCT) derived regional damage to the retinal ganglion cell-axonal complex (RGC-AC) and visual thresholds for each location of the Humphrey 24-2 visual field, in all stages of openangle glaucoma.METHODS. Patients with early, moderate, and advanced glaucoma were recruited from a tertiary glaucoma clinic. Humphrey 24-2 and 9-field Spectralis SD-OCT were acquired for each subject. Individual OCT volumes were aligned, nerve fiber layer (NFL), ganglion cell and inner plexiform layers (GCL+IPL) cosegmented. These layers were then partitioned into 54 sectors corresponding to the 24-2 grid. A Support Vector Machine was trained independently for each sector to predict the sector threshold, using these structural properties.RESULTS. One hundred twenty-two consecutive subjects, 43 early, 39 moderate, and 40 advanced, glaucoma were included (122 eyes). Average correlation coefficient (R) was 0.68 (0.47-0.82), and average root mean square error (RMSE) was 6.92 dB (3.93-8.68 dB). Prediction performance averaged over the entire field, superior hemifield, and inferior hemifield had R (RMSE) values of 0.77 (3.76), 0.80 (5.05), and 0.84 (3.80) dB, respectively.CONCLUSIONS. Predicting individual 24-2 visual field thresholds from structural information derived from nine-field SD-OCT local NFL and GCL+IPL thicknesses using the RGC-AC concept is feasible, showing the potential for the predictive ability of SD-OCT structural information for visual function. Ultimately, it may be feasible to complement and reduce the burden of subjective visual field testing in glaucoma patients with predicted function derived objectively from OCT.