Quantitative OCT analysis of idiopathic perifoveal telangiectasia
Quantitative OCT analysis of idiopathic perifoveal telangiectasia
复制标题
DOI：
10.1167/iovs.07-0478
复制
发表时间：
2008-05-01
影响因子：
4.4
通讯作者：
Sutter, Florian K. P.
中科院分区：
文献类型：
--
作者：
Barthelmes, Daniel;Gillies, Mark C.;Sutter, Florian K. P.
目的.识别和定量2型特发性中心凹周围毛细血管扩张症（IPT）患者的光学相干断层扫描（OCT）图像的特定变化。在一项前瞻性设计的观察性病例对照研究中，对14例连续IPT患者的28只眼睛进行了OCT检查，并与14例未受影响的对照受试者的眼睛进行了比较。对OCT图像的原始扫描数据的光反射率轮廓进行定量分析，以确定不同视网膜反射层之间的距离及其各自的反射率的差异。在四个独立的区域检查黄斑：（1）中央凹，（2）鼻侧中央凹周围，（3）颞侧中央凹周围，和（4）中央凹外。IPT眼的中央凹区、鼻侧和颞侧中心凹周围区视网膜变薄、感光细胞外节缩短、感光细胞椭球区反射率降低。此外，增加的反射率的外核层被发现在一个明确界定的地区的下颞部中央凹周围区域在所有受影响的眼睛。距离小窝2000 μ m以上的视网膜组织与正常眼的视网膜组织难以区分。结论。定量OCT分析显示了IPT中中央黄斑光感受器的独特和特异性变化，其可以从首次临床表现中检测到。这些变化可以作为额外的诊断工具。将外核层中的发现与组织学研究相关联，可能有助于确定反射率增加的性质，并更清楚地定义在这种情况下光感受器所持续的损伤类型。
PURPOSE. To identify and quantitate specific changes in optical coherence tomography (OCT) images of patients with type 2 idiopathic perifoveal telangiectasia (IPT).METHODS. In a prospectively designed, observational, case control study, 28 eyes of 14 consecutive patients with IPT were examined with OCT and compared with eyes of 14 unaffected control subjects. Light reflectivity profiles of raw scan data of OCT images were quantitatively analyzed for differences in distance between different retinal reflectivity layers and their respective reflectivities. Maculae were examined in four separate regions: ( 1) central fovea, ( 2) nasal perifovea, ( 3) temporal perifovea, and ( 4) outside the fovea.RESULTS. Retinal thinning, shortening of the photoreceptor outer segments and loss of reflectivity of the photoreceptor ellipsoid region were found in the central foveal region as well as the nasal and temporal perifoveal regions in eyes with IPT. In addition, increased reflectivity of the outer nuclear layer was found in a sharply demarcated area of the inferotemporal perifoveal region in all affected eyes. Retinal tissue located more than 2000 mu m away from the foveola was indistinguishable from that in normal eyes.CONCLUSIONS. Quantitative OCT analysis shows unique and specific changes in the photoreceptors of the central macula in IPT which can be detected from first clinical presentation. These changes may be of use as an additional diagnostic tool. Correlation of the findings in the outer nuclear layer with histologic studies may help identify the nature of the reflectivity increase and define more clearly the type of damage sustained by the photoreceptors in this condition.