Relationship between atrial natriuretic peptide and plasma volume during graded exercise with water immersion.
Relationship between atrial natriuretic peptide and plasma volume during graded exercise with water immersion.
复制标题
水浸分级运动时心房钠尿肽与血浆容量的关系。
DOI：
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发表时间：
1995
影响因子：
3.3
通讯作者：
Taketoshi Morimoto
中科院分区：
文献类型：
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作者：
Kei Nagashima;Hiroshi Nose;T. Yoshida;T. Kawabata;Y. Oda;A. Yorimoto;O. Uemura;Taketoshi Morimoto
为探讨心钠素（ANP）与运动时血浆容量（PV）下降的关系，我们测定了7名男性志愿者在空气（AE）和水浸（WE）条件下进行平板运动时PV和ANP的变化，并进行了空气和水中休息时间对照研究。在运动强度为峰值耗氧量（VO 2）的32%、49%、65%和78%时，通过肘前静脉导管采集血液样本。AE组血浆ANP仅在峰值VO 2的78%（29 +/- 5 pg/ml）时显著高于静息值[15 +/- 1（SE）pg/ml]，而WE组ANP在运动水平>峰值VO 2的49%时显著升高，在峰值VO 2的78%时达到68 +/- 9 pg/ml。尽管AE和WE的PV在VO 2>峰值VO 2的49%时显著降低（P < 0.01），但WE的PV较静息值的降低显著大于>峰值VO 2的65%时的AE（P < 0.01），并且在峰值VO 2的78%时的降低分别为-9.7 +/-0.8和-6.1 +/-1.7%。AE和WE在相应VO 2时PV降低的差异与ANP升高的差异呈强相关（r = -0.97; P < 0.01）。这些结果与运动过程中ANP可能参与液体从血管内向血管外转移的假设一致。
To assess the relationship between atrial natriuretic peptide (ANP) and the reduction in plasma volume (PV) during exercise, we measured changes in PV and ANP in seven male volunteers during treadmill exercise in air (AE) and with water immersion (WE) together with time control studies of rest in air and in water. Blood samples were collected from a catheter in the antecubital vein at exercise intensities of 32, 49, 65, and 78% of peak oxygen consumption (VO2). Plasma ANP in AE increased significantly from the resting value [15 +/- 1 (SE) pg/ml] only at 78% of peak VO2 (29 +/- 5 pg/ml), whereas ANP in WE increased significantly at exercise levels of > 49% of peak VO2 and reached 68 +/- 9 pg/ml at 78% of peak VO2. Although PV in AE and WE decreased significantly with VO2 of > 49% of peak VO2 (P < 0.01), the decrease from the resting value in WE was significantly greater than that in AE of > 65% of peak VO2 (P < 0.01) and the decreases at 78% of peak VO2 were -9.7 +/- 0.8 and -6.1 +/- 1.7%, respectively. The difference in the decrease in PV between AE and WE at corresponding VO2 correlated strongly with that in the increase in ANP (r = -0.97; P < 0.01). These results are consistent with the hypothesis that ANP may be involved in the fluid shift from the intra- to extravascular space during exercise.