Replicating chromatin: a tale of histones
Replicating chromatin: a tale of histones
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DOI：
10.1139/o08-102
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发表时间：
2009-02-01
期刊：
影响因子：
--
通讯作者：
Groth, Anja
中科院分区：
文献类型：
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作者：
Groth, Anja
染色质对于基因组稳定性和正确的基因表达起着至关重要的结构和功能作用。该组织必须在复制过程中在子链上复制，以保持表观遗传结构在基因序列上的正确覆盖。核小体构成染色质的结构框架，并携带指定高级组织和基因表达的信息。当复制叉穿过染色体时，核小体会暂时被破坏，从而使复制机制能够接触到 DNA。组蛋白回收与新沉积一起确保新生 DNA 链上的重新组装。本综述的目的是讨论如何在复制叉处处理新组蛋白和旧组蛋白，强调新的机制见解并重新审视旧的范式。
Chromatin serves structural and functional roles crucial for genome stability and correct gene expression. This organization must be reproduced on daughter strands during replication to maintain proper overlay of epigenetic fabric onto genetic sequence. Nucleosomes constitute the structural framework of chromatin and carry information to specify higher-order organization and gene expression. When replication forks traverse the chromosomes, nucleosomes are transiently disrupted, allowing the replication machinery to gain access to DNA. Histone recycling, together with new deposition, ensures reassembly on nascent DNA strands. The aim of this review is to discuss how histones - new and old are handled at the replication fork, highlighting new mechanistic insights and revisiting old paradigms.