Quantitative Coronary Arteriography: Estimation of Dimensions, Hemodynamic Resistance, and Atheroma Mass of Coronary Artery Lesions Using the Arteriogram and Digital Computation
Quantitative Coronary Arteriography: Estimation of Dimensions, Hemodynamic Resistance, and Atheroma Mass of Coronary Artery Lesions Using the Arteriogram and Digital Computation
复制标题
定量冠状动脉造影：利用动脉造影和数字计算估计冠状动脉病变的尺寸、血流动力学阻力和粥样斑块质量
作者：
B. Brown;E. Bolson;M. Frimer;H. Dodge
需要更准确的冠状动脉病变特征来评价冠状动脉疾病的短期和长期干预措施。一种分段动脉分析的方法已被开发，以最大限度地从冠状动脉造影获得的信息。冠状动脉病变从两个投影的、垂直的、35 mm的血管造影电影视图中追踪，并以数字形式传输到PDP 11/45计算机。使用导管及其位置作为缩放设备，补偿图像的放大和失真，以确定实际血管轮廓。两种观点相匹配;以数学方式构造血管中心线的空间表示;并且以沿该中心线的沿着增量计算正交血管直径。假设管腔为椭圆形，计算狭窄处直径和横截面积的绝对和百分比减小。然后计算更复杂的函数（积分粥样斑块质量、Poiffille阻力和孔口阻力），确定病变分析中不同步骤的准确性和可变性。± 150微米（SD）的尺寸精度是可行的。举例来说，患者与Prinzmetal的心绞痛和进行性冠状动脉疾病。
More accurate characterization of coronary artery lesions is needed for evaluation of short and long-term interventions in coronary disease. A method of segmental artery analysis has been developed to maximize the information obtained from coronary arteriograms. Coronary lesions are traced from two projected, perpendicular, 35 mm cineangiographic views and transmitted, in digital form, to a PDP 11/45 computer. Magnification and distortion of the image are compensated for in order to determine the actual vessel profiles, using the catheter and its location as a scaling device. The two views are matched; a spatial representation of the vessel centerline is constructed mathematically; and orthogonal vessel diameters are computed at increments along this centerline. Assuming an elliptical lumen, the absolute and percentage reduction in diameter and cross-sectional area in the stenosis are computed. More complex functions (integrated atheroma mass, Poiseuille resistance, and orifice resistance) are then calculated.The accuracy and variability of the different steps involved in lesion analysis have been determined. Dimensional accuracies of ± 150 microns (SD) are feasible. Examples are given of patients with Prinzmetal's angina and with progressive coronary disease.