Genotypechecker: an interactive tool for checking the inheritance consistency of genotyped pedigrees.
Genotypechecker: an interactive tool for checking the inheritance consistency of genotyped pedigrees.
复制标题
Genotypechecker：用于检查基因型谱系遗传一致性的交互式工具。
DOI：
10.1111/j.1365-2052.2011.02183.x
复制
发表时间：
2011
期刊：
影响因子：
2.4
通讯作者：
Andy Law
中科院分区：
文献类型：
--
作者：
T. Paterson;Andy Law
家谱基因型数据集中的数据点误差难以识别，并对下游遗传分析产生不利影响。我们提出GenotypeChecker，一个桌面软件工具，协助数据清理。该应用程序通过对系谱中的每个标记执行遗传检查算法来识别系谱/基因型数据集中可能的数据错误，并在探索性用户界面中突出显示不一致的遗传基因型。通过“屏蔽”可疑数据点并重新检查继承一致性，可以从数据集中确认和清除错误数据点。该软件、示例和文档可在http://bioinformatics.roslin.ac.uk/genotypechecker免费获得。
Datapoint errors in pedigree genotype data sets are difficult to identify and adversely affect downstream genetic analyses. We present GenotypeChecker, a desktop software tool for assisting data cleansing. The application identifies likely data errors in pedigree/genotype data sets by performing an inheritance-checking algorithm for each marker across the pedigree, and highlights inconsistently inherited genotypes in an exploratory user interface. By 'masking' suspect datapoints and rechecking inheritance consistency, erroneous datapoints can be confirmed and cleansed from the data set. The software, examples and documentation are freely available at http://bioinformatics.roslin.ac.uk/genotypechecker.