The effect of smoking status on survival following radiation therapy for non-small cell lung cancer
The effect of smoking status on survival following radiation therapy for non-small cell lung cancer
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DOI：
10.1016/j.lungcan.2003.11.012
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发表时间：
2004-06-01
期刊：
影响因子：
5.3
通讯作者：
Ostroff, JS
中科院分区：
文献类型：
--
作者：
Fox, JL;Rosenzweig, KE;Ostroff, JS
吸烟的危害众多且众所周知，包括与肺癌的因果关系。本研究调查了初诊时的吸烟状况对非小细胞肺癌（NSCLC）放射治疗的影响。我们确定了1991年至2001年间接受根治性放疗或放化疗且有完整吸烟史的237名患者。中位年龄为73岁，男性占56%。分期分布如下：I/II期 - 27%，IIIA期 - 27%，IIIB期 - 45%，复发期 - 1%。根据疾病分期分层计算从治疗开始时起的两年总生存率。从治疗结束后的中位随访时间为13个月。在I/II期疾病患者中，当前吸烟者的两年生存率为41%，中位生存期为13.7个月，而非吸烟者的两年生存率为56%，中位生存期为27.9个月（P = 0.01）。III期疾病患者的总生存率没有显示出任何显著差异。在两个分期中，癌症特异性生存率也没有显著差异。总之，在被诊断为早期疾病的非小细胞肺癌患者中，当前吸烟者在放射治疗后的生存预后较差。（C）2003爱思唯尔爱尔兰有限公司。保留所有权利。
The dangers of cigarette smoking are numerous and well-known, including the causal relationship to lung cancer. This study investigates the effect that smoking status at initial consultation has on radiation therapy for non-small cell lung cancer (NSCLC).We identified 237 patients treated between 1991 and 2001 with definitive radiation or chemoradiation who had complete smoking histories. Median age was 73, with 56% males. Distribution by stage was as follows: I/II-27%, IIIA-27%, IIIB-45%, recurrent-1%. Two-year overall survival, stratified by stage of disease, was calculated from the time of initiation of treatment. Median follow-up time from the end of treatment was 13 months. Among those with stage I/II disease, current smokers had a 2-year survival rate of 41% and a median survival of 13.7 months while non-smokers had a 2-year survival of 56% and a median survival of 27.9 months (P = 0.01). Patients with stage III disease did not show any significant differences in overall survival. There were no significant differences in cancer-specific survival in either stage. In conclusion, among NSCLC patients diagnosed with early stage disease, current smokers have a poorer prognosis for survival after radiation therapy. (C) 2003 Elsevier Ireland Ltd. All rights reserved.