Preoperative circulating platelet, neutrophil, and lymphocyte counts predict survival in oral cancer
Preoperative circulating platelet, neutrophil, and lymphocyte counts predict survival in oral cancer
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术前循环血小板、中性粒细胞和淋巴细胞计数可预测口腔癌的生存率
DOI：
10.1111/odi.13049
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发表时间：
2019-05-01
期刊：
影响因子：
3.8
通讯作者：
Cheng, Jie
中科院分区：
文献类型：
--
作者：
Diao, Pengfei;Wu, Yaping;Cheng, Jie
目的循环免疫炎性细胞已被越来越多地认为是癌症预后的生物标志物。在这里，我们试图评估手术前外周血血小板、中性粒细胞、淋巴细胞数量对口腔鳞癌(OSCC)患者预后的价值。资料与方法对309例在本院接受手术治疗的原发口腔鳞癌患者进行回顾性研究。收集了详细的人口学、临床病理、实验室和随访数据。Kaplan-Meier分析和Cox回归分析评估预后价值。通过COX回归分析计算每种细胞的回归系数，设计了一种新的预后风险评分，即基于术前血小板、中性粒细胞和淋巴细胞的PNL评分。结果高血小板计数(>；=266x10(9)/L)，中性粒细胞计数(>；=2.8x10(9)/L)，PNL评分，低淋巴细胞计数(
Objective Circulating immune-inflammatory cells have been increasingly recognized as robust prognostic biomarkers in cancer. Here, we sought to evaluate the prognostic values of preoperative peripheral platelet, neutrophil, lymphocyte quantitation in patients with primary oral squamous cell carcinoma (OSCC). Materials and methods A total number of 309 patients with primary OSCC surgically treated at our institutions were retrospectively included. Detailed demographic, clinicopathological, laboratory, and follow-up data were collected. The Kaplan-Meier analysis and Cox regression assay were performed to assess the prognostic values. A new prognostic risk score was developed and designed as PNL (platelet-neutrophil-lymphocyte) score based on combined preoperative platelets, neutrophils, and lymphocytes via calculating the regression coefficients of each type of cell by Cox regression analysis. Results High platelet counts (>= 266 x 10(9)/L), neutrophil counts (>= 2.8 x 10(9)/L), PNL scores, and low lymphocyte counts (