PLASMA SOMATOMEDIN ACTIVITY AND DIABETIC RETINOPATHY
PLASMA SOMATOMEDIN ACTIVITY AND DIABETIC RETINOPATHY
复制标题
血浆生长调节素活性与糖尿病视网膜病变
作者：
I. Ashton;T. Dornan;A. Pocock;R. Turner;A. Bron
通过兔软骨细胞生物测定法测定了持续11-28年的胰岛素依赖型糖尿病成年患者血浆中的生长激素活性。通过眼科检查或荧光素血管造影评估，背景性或增殖性视网膜病变患者的平均生长素活性为1.42±0.65 U/ml (n= 20)，显著高于年龄和体重匹配的对照组（1.05±0.22 U/ml, n= 9）。相比之下，没有视网膜病变的患者的生长抑素活性没有升高（1.16±0.33 U/ml, n= 10）。
Somatomedin activity was measured by a rabbit chondrocyte bioassay in plasma of adult patients with insulin‐dependent diabetes of 11–28 years duration. Mean somatomedin activity in patients with background or proliferative retinopathy, assessed by ophthalmoscopy or fluorescein angiography, was 1·42 ± 0·65 U/ml (n= 20) which was significantly greater than in age‐ and weight‐matched control subjects (1·05 ± 0·22 U/ml, n= 9). In contrast, somatomedin activity was not raised in patients who had no retinopathy (1·16 ± 0·33 U/ml, n= 10).