Ion/water channels for embryo implantation barrier.
Ion/water channels for embryo implantation barrier.
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DOI：
10.1152/physiol.00039.2013
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发表时间：
2014-05
期刊：
影响因子：
8.4
通讯作者：
Xin-Mei Liu;Dan Zhang;Ting-ting Wang;J. Sheng;He-feng Huang
中科院分区：
文献类型：
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作者：
Xin-Mei Liu;Dan Zhang;Ting-ting Wang;J. Sheng;He-feng Huang
成功的植入涉及三个不同的过程，即胚胎并置、附着和穿透子宫内膜腔上皮以建立与母体的血管连接。穿透后，上皮下的基质细胞分化并包围胚胎，形成胚胎着床屏障，阻止有害物质进入胚胎。发现许多离子/水通道蛋白参与胚胎植入过程。首先，离子/水通道蛋白在建立静息膜电位、通过控制跨细胞膜的离子流形成动作电位和其他电信号方面发挥着经典作用。其次，大多数离子/水通道蛋白受类固醇激素（雌激素或黄体酮）调节，这可能对胚胎植入具有重要影响。最后但并非最不重要的一点是，这些蛋白质并不将自身限制为纯粹的通道，而且一旦被其配体/刺激物激活，也可充当一系列后果的引发剂。在此，我们讨论近年来关于离子/水通道对妊娠早期胚胎着床屏障构建的贡献的新见解。
Successful implantation involves three distinct processes, namely the embryo apposition, attachment, and penetration through the luminal epithelium of the endometrium to establish a vascular link to the mother. After penetration, stromal cells underlying the epithelium differentiate and surround the embryo to form the embryo implantation barrier, which blocks the passage of harmful substances to the embryo. Many ion/water channel proteins were found to be involved in the process of embryo implantation. First, ion/water channel proteins play their classical role in establishing a resting membrane potential, shaping action potentials and other electrical signals by gating the flow of ions across the cell membrane. Second, most of ion/water channel proteins are regulated by steroid hormone (estrogen or progesterone), which may have important implications to the embryo implantation. Last but not least, these proteins do not limit themselves as pure channels but also function as an initiator of a series of consequences once activated by their ligand/stimulator. Herein, we discuss these new insights in recent years about the contribution of ion/water channels to the embryo implantation barrier construction during early pregnancy.