EARLY HUMAN DECIDUAL CELLS EXHIBIT NK ACTIVITY AGAINST THE K562 CELL-LINE BUT NOT AGAINST 1ST TRIMESTER TROPHOBLAST
EARLY HUMAN DECIDUAL CELLS EXHIBIT NK ACTIVITY AGAINST THE K562 CELL-LINE BUT NOT AGAINST 1ST TRIMESTER TROPHOBLAST
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DOI：
10.1016/0008-8749(89)90382-1
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发表时间：
1989-02-01
影响因子：
4.3
通讯作者：
LOKE, YW
中科院分区：
文献类型：
--
作者：
KING, A;BIRKBY, C;LOKE, YW
研究了培养的妊娠早期人类滋养层细胞对 NK 细胞裂解的敏感性。滋养层细胞对外周血和蜕膜中的 NK 细胞具有抵抗力。然而，通过酶分解提取的蜕膜细胞确实对 NK 敏感细胞系 K562 表现出细胞毒性。讨论了这些发现与囊胚成功植入的相关性。
The susceptibility of cultured first trimester human trophoblast cells to lysis by NK cells has been studied. Trophoblast cells are resistant to lysis by NK cells from both peripheral blood and decidua. However, decidual cells extracted by enzymatic disaggregation do exhibit cytotoxicity against the NK-sensitive cell line K562. The relevance of these findings to successful implantation of the blastocyst is discussed.