Role of microRNA in the detection, progression, and intervention of acute kidney injury
Role of microRNA in the detection, progression, and intervention of acute kidney injury
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microRNA 在急性肾损伤的检测、进展和干预中的作用
DOI：
10.1177/1535370217749472
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发表时间：
2018-01-01
影响因子：
3.2
通讯作者：
Zhang, Wen
中科院分区：
文献类型：
--
作者：
Zou, Yan-Fang;Zhang, Wen
急性肾损伤以肾功能急剧下降为特征，是住院患者常见且重要的并发症。急性肾损伤的病理机制主要与免疫激活和炎症反应有关。由于急性肾损伤住院患者的发病率和死亡率较高，因此迫切需要鉴定用于评估风险、早期诊断、评估预后和对损伤严重程度进行分类的生物标志物。此外，需要对急性肾损伤的发展和潜在的治疗靶点进行调查。当microRNA首次在秀丽隐杆线虫中发现时，加里·鲁夫昆的实验室发现了第一个microRNA靶基因。这两项重要发现共同证实了一种新的转录后基因调控机制的存在。考虑到血清肌酐检测在阿基的早期检测中经常失败，检测microRNA作为早期诊断生物标志物已经显示出巨大的潜力。许多研究已经确定了可以作为检测急性肾损伤的生物标志物的microRNA。此外，由于microRNA可以通过影响多种信号通路的数百或数千个靶标来控制多种蛋白质的表达，因此关于microRNA在阿基进展中的功能的研究数量正在增加。本文主要对microRNA作为生物标志物的研究及其在急性肾损伤中的作用进行探讨。首先，我们讨论了miRNA作为生物标志物的潜在优势和局限性。其次，对miRNA在阿基发病过程中的作用进行了综述。最后，我们展望了miRNA作为治疗靶点干预阿基的潜力和优势。
Acute kidney injury, characterized by sharply decreased renal function, is a common and important complication in hospitalized patients. The pathological mechanism of acute kidney injury is mainly related to immune activation and inflammation. Given the high morbidity and mortality rates of hospitalized patients with acute kidney injury, the identification of biomarkers useful for assessing risk, making an early diagnosis, evaluating the prognosis, and classifying the injury severity is urgently needed. Furthermore, investigation into the development of acute kidney injury and potential therapeutic targets is required. While microRNA was first discovered in Caenorhabditis elegans, Gary Ruvkun’s laboratory identified the first microRNA target gene. Together, these two important findings confirmed the existence of a novel post-transcriptional gene regulatory mechanism. Considering that serum creatinine tests often fail in the early detection of AKI, testing for microRNAs as early diagnostic biomarkers has shown great potential. Numerous studies have identified microRNAs that can serve as biomarkers for the detection of acute kidney injury. In addition, as microRNAs can control the expression of multiple proteins through hundreds or thousands of targets influencing multiple signaling pathways, the number of studies on the functions of microRNAs in AKI progression is increasing. Here, we mainly focus on research into microRNAs as biomarkers and explorations of their functions in acute kidney injury. Impact statement Firstly, we have discussed the potential advantages and limitations of miRNA as biomarkers. Secondly, we have summarized the role of miRNA in the progress of AKI. Finally, we have made a vision of miRNA’s potential and advantages as therapeutic target intervention AKI.