A HOUSEHOLD-BASED, CASE-CONTROL STUDY OF ENVIRONMENTAL-FACTORS ASSOCIATED WITH HANTAVIRUS PULMONARY SYNDROME IN THE SOUTHWESTERN UNITED-STATES
A HOUSEHOLD-BASED, CASE-CONTROL STUDY OF ENVIRONMENTAL-FACTORS ASSOCIATED WITH HANTAVIRUS PULMONARY SYNDROME IN THE SOUTHWESTERN UNITED-STATES
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DOI：
10.4269/ajtmh.1995.52.393
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发表时间：
1995-05-01
影响因子：
3.3
通讯作者：
PETERS, CJ
中科院分区：
文献类型：
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作者：
CHILDS, JE;KREBS, JW;PETERS, CJ
1993年6月至8月，在美国西南部汉坦病毒肺综合征（HPS）爆发期间，训练有素的环境评估小组在17个病例-患者家庭进行了调查，并进行了对照。对与啮齿动物丰度有关的变量进行了量化，并在家庭周围和家庭内部进行了标准化的啮齿动物诱捕。大多数家庭位于松树，杜松植被带，有没有显着差异的情况下，控制住的房子类型。唯一的环境因素，区分情况下家庭控制显着较高的小啮齿动物密度（中位数陷阱成功的情况下网站= 17.3%，12.7%的近控制，和8.3%的远控制）。鹿鼠（Peromyscus maniculatus）汉坦病毒感染的频率在病例和对照家庭之间没有显著差异，抗体阳性率为27.5-32.5%。啮齿动物粪便污染指数略高的情况下房子。数据表明，较高的啮齿动物密度与发生HPS病例的家庭有关。控制啮齿动物数量和减少啮齿动物进入住宅的策略可能会降低人类感染的风险。
During an outbreak of hantavirus pulmonary syndrome (HPS) in the southwestern United States, trained environmental assessment teams conducted surveys at 17 case-patient homes and matched controls from June through August 1993. Variables related to rodent abundance were quantified and standardized rodent trapping was conducted around and within households. The majority of households were located in pinon-juniper vegetation zones, and there were no significant differences in the type of house in which cases and controls lived. The only environmental factor that distinguished case households from controls was significantly higher small rodent densities (median trap success for case sites = 17.3%, 12.7% for near controls, and 8.3% for far controls). Frequency of hantaviral infection in deer mice (Peromyscus maniculatus) did not vary significantly among households of cases and controls, with a range of 27.5-32.5% antibody-positive. Indices of rodent fecal contamination were slightly higher in case houses. The data indicate that higher rodent densities were associated with households in which HPS cases occurred. Strategies that control rodent numbers and decrease rodent access to dwellings may reduce risk of human infection.