Electroelastic unpinning of rotating vortices in biological excitable media
Electroelastic unpinning of rotating vortices in biological excitable media
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DOI：
10.1103/physreve.85.031915
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发表时间：
2012-03-28
影响因子：
2.4
通讯作者：
Gizzi, A.
中科院分区：
文献类型：
--
作者：
Cherubini, C.;Filippi, S.;Gizzi, A.
可兴奋生物介质中的螺旋波与病理情况有关。在心脏中，一个被障碍物固定的动作电位漩涡必须通过除颤方案去除，该方案通过电生理非线性数学模型在理论上进行微调。然而，心脏组织是一种电弹性介质，其电学性质受到大变形的强烈影响。在本文中，我们专门研究了电弹性钉-解钉机制，以便在预先存在的理论模型除颤场景中包括心脏收缩。基于二维最小机电模型，我们用数值方法证明了以障碍物大小、起搏位置和频率为特征的解钉带的存在。类似的数值模拟，在没有弹性耦合的情况下进行，与电弹性研究相比，显示出很小的差异，这表明在这种特定的钉-解动力学情况下，弹性的作用并不突出。
Spiral waves in excitable biological media are associated with pathological situations. In the heart an action potential vortex pinned by an obstacle has to be removed through defibrillation protocols fine-tuned theoretically by using electrophysiological nonlinear mathematical models. Cardiac tissue, however, is an electroelastic medium whose electrical properties are strongly affected by large deformations. In this paper we specifically investigate the electroelastic pinning-unpinning mechanism in order to include cardiac contraction in the preexisting theoretically modeled defibrillation scenarios. Based on a two-dimensional minimal electromechanical model, we show numerically the existence of an unpinning band characterized by the size of the obstacle, the pacing site, and the frequency. Similar numerical simulations, performed in the absence of elastic coupling, show small differences in comparison with the electroelastic studies, suggesting for this specific scenario of pinning-unpinning dynamics a nonprominent role of elasticity.