Natural recombinant between equine herpesviruses 1 and 4 in the ICP4 gene
Natural recombinant between equine herpesviruses 1 and 4 in the ICP4 gene
复制标题
DOI：
10.1111/j.1348-0421.2005.tb03716.x
复制
发表时间：
2005-01-01
影响因子：
2.6
通讯作者：
Fukushi, H
中科院分区：
文献类型：
--
作者：
Pagamjav, O;Sakata, T;Fukushi, H
Equine herpesvirus 1 (EHV-1) is a pathogen causing rhinopneumonia in young horses, abortion in mares, and myeloencephalitis in adult horses. Two types, EHV-1 P and EHV-1 B, have recently been dominant among 16 electropherotypes. EHV-1 P and EHV-1 B viruses were compared by long and accurate polymerase chain reaction (LA-PCR) and restriction fragment length polymorphism (RFLP) analysis. Differences in restriction sites were found to be focused in ORF64, which encodes the infected cell protein 4 (ICP4), and downstream of the ICP4 gene. The 3'-end and downstream of ICP4 gene of EHV-1 B were found to be replaced by the corresponding region of EHV-4, indicating that EHV-1 B is a naturally occurring recombinant virus between progenitors of EHV-1 P and EHV-4. This is the first report showing a natural interspecies recombinant in alphaherpesviruses.
