Aneuploidy and progression in promoted preneoplastic foci during chemical hepatocarcinogenesis in the rat.
Aneuploidy and progression in promoted preneoplastic foci during chemical hepatocarcinogenesis in the rat.
复制标题
大鼠化学性肝癌发生过程中促进癌前病灶的非整倍性和进展。
DOI：
10.1016/0304-3835(91)90087-x
复制
发表时间：
1991
期刊：
影响因子：
9.7
通讯作者：
Hei,TK
中科院分区：
文献类型：
--
作者：
Sudilovsky,O;Hei,TK
Since a number of rat hepatocarcinomas are aneuploid, the model DNA content of enzymealtered foci was determined cytospectrophotometrically, to assess if ploidy changes occur before cancer is established. male F344 rats treated with diethylnitrosamine and promoted with a choline-deficient, phenobarbital supplemented diet showed in most enzymealtered foci a multimodal ploidy distribution with diploid, tetraploid and octoploid peaks. A minority of foci, however, exhibited an aneuploid pattern. This change in ploidy reflects irreversible genomic alterations, indicative of tumor progression. Thus, promotion and progression may coexist simultaneously in this model of carcinogenesis, long before hepatomas can be diagnosed.
