Catheter-directed gastric artery chemical embolization for modulation of systemic ghrelin levels in a porcine model: Initial experience
Catheter-directed gastric artery chemical embolization for modulation of systemic ghrelin levels in a porcine model: Initial experience
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DOI：
10.1148/radiol.2441060790
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发表时间：
2007-07-01
期刊：
影响因子：
19.7
通讯作者：
Patel, Tarak
中科院分区：
文献类型：
--
作者：
Arepally, Aravind;Barnett, Brad P.;Patel, Tarak
Purpose: To prospectively test, in a porcine model, the hypothesis that use of catheter-directed gastric artery chemical embolization (GACE) can result in substantial suppression of systemic ghrelin levels.Materials and Methods: The institutional animal care and use committee approved this study. Adult healthy swine (40 - 45 kg, n = 8) were tested. GACE was performed by infusing morrhuate sodium selectively into the left gastric artery. Six swine (animals A - F) underwent left GACE by using a dose- escalating regimen of morrhuate sodium, whereas two control swine underwent a sham procedure. Weight and fasting plasma ghrelin levels were compared in swine at baseline and at weeks 1-4. At week 4, stomachs were excised and analyzed. Analysis of the change in ghrelin values and weight was performed with both paired t test and unpaired Student t test.Results: In control swine ( n = 2), there was no significant difference in ghrelin values before ( 844.8 pg/ mL +/- 40 [ standard deviation]) and after ( 997 pg/ mL +/- 93) the procedure ( P = .5). Swine that received a low dose of morrhuate sodium (animals A-D) showed a significant increase in serum ghrelin values from 683.7 pg/ mL +/- 241 to 1555.9 pg/ mL +/- 312 ( P = .002). At a higher dose, the mean baseline ghrelin values decreased from 466 pg/ mL to 187 pg/ mL +/- 162. Weight changes of + 1.4% and + 8.6% were seen in swine that underwent GACE and control swine, respectively. Histochemical staining showed preservation of overall tissue architecture and parietal cells.Conclusion: Use of GACE can result in increased or suppressed ghrelin levels. (c) RSNA, 2007.
