Shared Ancestry between a Newfound Mole-Borne Hantavirus and Hantaviruses Harbored by Cricetid Rodents
Shared Ancestry between a Newfound Mole-Borne Hantavirus and Hantaviruses Harbored by Cricetid Rodents
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DOI：
10.1128/jvi.02450-10
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发表时间：
2011-08-01
影响因子：
5.4
通讯作者：
Yanagihara, Richard
中科院分区：
文献类型：
--
作者：
Kang, Hae Ji;Bennett, Shannon N.;Yanagihara, Richard
在多种鼩鼱（鼩鼱目、鼩科）和鼹鼠（鼹鼠科）中发现的遗传上不同的汉坦病毒对啮齿动物（啮齿类、鼠科和仓鼠科）是主要储存宿主的传统观点提出了质疑，并表明汉坦病毒的进化史比之前假设的要复杂得多。我们现在报告罗克波特病毒 (RKPV)，这是一种在 1986 年收集于德克萨斯州罗克波特的东部鼹鼠（水生扇贝）档案组织中发现的汉坦病毒。全长 S、M 和 L 基因组片段的成对比较表明 RKPV 和其他 soricomorph 传播的汉坦病毒之间的序列相似性较低。使用最大似然法和贝叶斯方法进行的系统发育分析表明，RKPV 与仓鼠传播的汉坦病毒具有最近的共同祖先。东鼹鼠广泛分布于美国东部，与已知携带汉坦病毒的仓鼠类啮齿类动物同域共生，这增加了在遥远的过去发生宿主转换事件的可能性。我们的研究结果需要对当今啮齿动物和鼹鼠群落中汉坦病毒的溢出和跨物种传播动态进行更详细的调查。
Discovery of genetically distinct hantaviruses in multiple species of shrews (order Soricomorpha, family Soricidae) and moles (family Talpidae) contests the conventional view that rodents (order Rodentia, families Muridae and Cricetidae) are the principal reservoir hosts and suggests that the evolutionary history of hantaviruses is far more complex than previously hypothesized. We now report on Rockport virus (RKPV), a hantavirus identified in archival tissues of the eastern mole (Scalopus aquaticus) collected in Rockport, TX, in 1986. Pairwise comparison of the full-length S, M, and L genomic segments indicated moderately low sequence similarity between RKPV and other soricomorph-borne hantaviruses. Phylogenetic analyses, using maximum-likelihood and Bayesian methods, showed that RKPV shared a most recent common ancestor with cricetid-rodent-borne hantaviruses. Distributed widely across the eastern United States, the fossorial eastern mole is sympatric and syntopic with cricetid rodents known to harbor hantaviruses, raising the possibility of host-switching events in the distant past. Our findings warrant more-detailed investigations on the dynamics of spillover and cross-species transmission of present-day hantaviruses within communities of rodents and moles.